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Skip to Search Results- 1Chavali Venkata Subramanya, Ravi Shankar
- 1Gavina, Kenneth C
- 1Gujral, Naiyana
- 1Heppner, Ian N
- 1Iwashkiw, Jeremy, A
- 1Kinsella, Rachel L.
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Fall 2013
Gluten-sensitive enteropathy, called Celiac disease (CD), is one of the most frequent autoimmune diseases, occurring in 1% people worldwide, upon gliadin ingestion. Currently, the only treatment available for CD individual is a strict life-long gluten-free diet. Chicken egg yolk immunoglobulin Y...
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Characterization of the Type VI Secretion System in the Bacterial Pathogen Acinetobacter baumannii
DownloadFall 2016
Antibiotic resistant bacteria that cause hospital-acquired infections are a mounting concern for healthcare systems globally. Multidrug resistant (MDR) Acinetobacter baumannii has emerged as a common cause of nosocomial infections, and some isolates are now pandrug resistant. These infections can...
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Clinical impact of submicroscopic malaria on delivery outcomes and the role of VAR2CSA antibodies in pregnant women from Colombia
DownloadFall 2018
Malaria caused by the genus Plasmodium (P.) is one of the oldest and most important parasitic infections globally. Pregnant women are at an increased risk for malaria, where the disease poses a significant risk to both maternal and child health. Better diagnosis of malaria can have an immediate...
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Spring 2013
Chavali Venkata Subramanya, Ravi Shankar
The In-gel polymerase chain reaction (PCR) technology developed by our group at the University of Alberta makes use of PCR reagents entrapped within nano-liter polyacrylamide gels. To adapt this technology for use at the point of care, methods were developed to preserve gel-based PCR reagents by...
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Exploiting novel Acinetobacter Oligosaccharyltransferases for the development of glycoconjugate vaccines against the Pneumococcus
DownloadSpring 2016
Vaccines bring many diseases under control, an example of which is the Streptococcus pneumoniae, or the Pneumococcus. Pneumococcus is one of the leading causes of meningitis in children under 5 years, and is responsible for almost a million child deaths annually, with more than 90 serotypes...
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Identification and Exploitation of Oligosaccharyltransferase Dependent Bacterial Glycosylation Systems
DownloadFall 2014
Protein glycosylation, the covalent attachment of carbohydrates to amino acids, was once thought to be a unique attribute of Eukaryotes and select bacteria. However, both N- (attached to asparagine) and O- (attached to serine or threonine) glycosylation systems have been identified in an ever...
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Investigating the roles of O-linked Protein Glycosylation and Type Two Secretion in the Pathogenesis of Acinetobacter
DownloadSpring 2017
The Acinetobacter baumannii, A. nosocomialis and A. pittii are Gram-negative opportunistic human pathogens that are of importance to the healthcare system particularily because of their resistance to antibiotics. The thesis below focuses on investigating two virulence attributes of Acinetobacter...
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Fall 2011
In recent decades, condition-based maintenance has been acknowledged as a cost-effective maintenance program and widely used in many engineering systems. Diagnostics and prognostics are critical components of condition-based maintenance, responsible for providing information about present and...
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Towards a Better Understanding of Poly(N-isopropylacrylamide) Microgel-Based Etalons and their Continued Development in Diagnostics
DownloadFall 2013
Poly(N-isopropylacrylamide) (pNIPAm) microgel-based etalons are photonic materials that exhibit color based on temperature or other environmental stimuli. These materials provide a new and unique method for biosensing and other applications. Therefore it is important to understand these materials...