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Skip to Search Results- 78Graduate and Postdoctoral Studies (GPS), Faculty of
- 78Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 10Medicine and Dentistry, Faculty of
- 9Medicine and Dentistry, Faculty of/Alberta Research Centre for Health Evidence (ARCHE)
- 7Agricultural, Food and Nutritional Science, Department of
- 7Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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2014
van Zanten, S.V., Chang, H.J., Morse, A., Lefebvre, M., Goodman, K.J.
Introduction. Helicobacter pylori infection is an emerging health concern to some northern Canadian Aboriginal communities and their clinicians. Clinicians in the north perceive H. pylori infection to be a major clinical problem because they find H. pylori infection in many patients evaluated for...
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Adiposity and fat loss in cancer: Exploring the prognostic significance and underlying mechanisms of adipose alterations in cancer
DownloadSpring 2017
During cancer progression, many patients will experience some degree of wasting of both muscle and adipose tissue. However, little is-known about adipose tissue alterations after a cancer diagnosis. Therefore, this research was conducted to first understand the prognostic significance of adipose...
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Fall 2016
Antemortem identification of Creutzfeldt-Jakob disease (CJD) patients is initially based upon clinical presentation of the disease. Symptoms are assessed in combination with results from cerebrospinal fluid (CSF) analysis, electroencephalography (EEG), magnetic resonance imaging (MRI), and...
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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
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Fall 2009
There is substantial evidence of the elevated risk of cancer among individuals with type 2 diabetes. Very little is known, however, about the role that antidiabetic therapies play in this relationship. The objective of this program of research was to examine whether there is a therapeutic risk...
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Application of ROC curve analysis to metabolomics data sets for the detection of cancer in a mouse model
DownloadFall 2010
The goal of this study was to show that quantifiable metabolic changes may be used to screen for cancer. NIH III nude mice (n=22) were injected with human GBM cells, with daily urine samples collected pre and post-injection. 14 mice were injected with saline to serve as controls. The...
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Attitudes and Opinions of Pediatric Physicians Regarding Decisions to Withdraw or Withhold Medically-Provided Hydration or Nutrition
DownloadFall 2013
Deciding to forego intravenous hydration (IH) and medically-provided nutrition (MPN) in pediatric patients remains controversial. Minimal published research exists that explores the attitudes and approaches of pediatricians who are making these decisions. This survey explored attitudes and...
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B cell Tolerance Mechanisms Following ABO-incompatible Infant Heart Transplant: A Potential Role for CD22
DownloadSpring 2015
Due to presumed immune immaturity, infants are able to accept heart transplants across the ABO barrier, a procedure that would result in catastrophic consequences if performed in adults. Our group has demonstrated that following ABO-incompatible heart transplantation (ABOi HTx), infants develop...
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Fall 2012
Taxane chemotherapy is widely used in the treatment of breast cancer. Despite its widespread clinical use, the molecular mechanisms of paclitaxel induced apoptosis remain unclear. Our laboratory has identified an important role for the BH3-only protein, BAD, in the paclitaxel induced cell death...