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Skip to Search Results- 2Kinnaird, Adam
- 1Abdulsalam Alharbi
- 1Aktary, Zackie M
- 1Alenazi, Abdulrahman, F
- 1Alolayan, Waad Riyad
- 1Alshamsan, Aws
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Molecular Prognostication of Oral Cavity Squamous Cell Carcinoma by Tissue Microarray Analysis
DownloadSpring 2018
AimsOral cavity squamous cell carcinoma (OCSCC) is a molecularly heterogeneous disease, which is thought to account for differences in treatment response between patients who have otherwise similar characteristics. Cancer biomarkers provide a means of molecular classification, which can be of...
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Muscle Abnormalities in cancer patients: Exploring the biological characteristics of skeletal muscle of cancer patients
DownloadFall 2019
Computed tomography-derived muscle measures of sarcopenia and low muscle radiodensity have been associated with poor outcomes in cancer patients, however, the biological characteristics of the muscle in this population are not well understood. This research was conducted to first evaluate muscle...
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Physical Therapy Interventions for Children and Adolescents with Cancer: Collating the Evidence from Research and Clinical Practice
DownloadSpring 2018
Purpose: Children and adolescents with cancer who undergo cancer treatment are at high risk of developing serious late and long-term physical effects, many of which may be amenable to physical therapy (PT). Little is known about the benefits of PT or the services currently provided to address...
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Preliminary validation of a computer-based approach to find new lead molecules targeting the oncogenic Forkhead box M1 transcription factor
DownloadFall 2017
The upregulation of the forkhead box M1 (FOXM1) transcription factor is directly correlated with cancer initiation, invasion, and drug resistance. Because the overexpression of FOXM1 is considered an important factor in carcinogenesis, this protein could be a relevant drug target in cancer...
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Regulation of Anti-tumor Immunity in Colorectal Cancer by Interaction of Exosome Immune Complexes with Fc gamma Receptors
DownloadSpring 2019
Targeted therapy is difficult for colorectal cancer (CRC) due to lack of conserved tumor associated antigens (TAA). Immunotherapies for CRC directed at TAA that can overcome intestinal tolerance need to be developed to improve survival of CRC patients. Exosomes are extracellular vesicles secreted...
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Repositioning study of flubendazole for treating lung cancer and meningoencephalitis using an oral lipid nanosystem
DownloadFall 2023
Nanoemulsions have wide application, presenting several properties such as the solubilization of poorly soluble drugs in water, promoting the increase of their bioavailability, allowing greater stability of the formulation and, due to its property as a carrier, promoting their modified release....
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Spectral Editing for Detection of Oncologically Relevant Metabolites with In-Vivo Magnetic Resonance Spectroscopy at 9.4 T
DownloadFall 2019
Short echo time (TE) magnetic resonance spectroscopy (MRS) techniques with spectral fitting are commonly employed approaches for brain metabolite quantification at 9.4 T. However, there is a significant overlap of peaks in short-TE spectra, even at 9.4 T. To better resolve resonances, spectral...
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Fall 2012
The protein p53 is a key regulator of cellular response to a wide variety of stresses. In cancerous cells inhibitory regulators of the p53 protein such as MDM2 and MDMX are often overexpressed. In silico techniques could be used to inform the selection of interactions to target with novel drug...
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Survival Benefit of Chemotherapy in Oropharyngeal Cancer Patients Treated with Surgery and Post-Operative Radiation
DownloadFall 2017
Oropharyngeal squamous cell carcinoma (OPSCC) is the third most common cancer of the head and neck. The incidence of all subtypes of head and neck squamous cell carcinoma has decreased over the past 30 years in Canada and most of the world except for OPSCC. The increasing incidence of OPSCC over...
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Synthesis and Characterization of Novel Radiolabelled Substrates for Imaging of GLUT5 Expression in Human Breast Cancer Using Positron Emission Tomography
DownloadFall 2012
Overactive glucose transport and metabolism has been widely recognized as one of the fundamental hallmarks of cancer and its progression. The facilitative glucose transporter GLUT1 is widely overexpressed in many tumor types compared to their untransformed counterparts. Due to this, the glucose...