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Skip to Search Results- 1Aktary, Zackie M
- 1Brandwein, Daniel
- 1Craik, Alison C
- 1Forbrich, Alexander E
- 1Goldansaz, Seyed Ali
- 1Gushue, Danielle L
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Fall 2016
Antemortem identification of Creutzfeldt-Jakob disease (CJD) patients is initially based upon clinical presentation of the disease. Symptoms are assessed in combination with results from cerebrospinal fluid (CSF) analysis, electroencephalography (EEG), magnetic resonance imaging (MRI), and...
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Fall 2012
Taxane chemotherapy is widely used in the treatment of breast cancer. Despite its widespread clinical use, the molecular mechanisms of paclitaxel induced apoptosis remain unclear. Our laboratory has identified an important role for the BH3-only protein, BAD, in the paclitaxel induced cell death...
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Spring 2022
Carotid atherosclerosis is responsible for 15-25% of the nearly 8 million first-ever ischemic strokes that occur each year worldwide. This proportion has remained constant over the past three decades, thus suggesting that some patients with carotid atherosclerosis currently receive suboptimal...
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Evaluating the Role of Bacterial Lipopolysaccharide on Etiology and Pathogenesis of Transmissible Spongiform Encephalopathies
DownloadFall 2014
Transmissible spongiform encephalopathies (TSEs) or otherwise known as prion diseases are a class of fatal neurodegenerative diseases related to irreversible brain damage. Presently, there is no effective treatment or preventive strategy for this disease because the etiology and biological...
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Fall 2021
Background Human Immunodeficiency Virus (HIV) is a major cause of mortality and morbidity globally. Vertical transmission is the primary mode of HIV acquisition among infants. Although successful interventions have reduced vertical transmission to less than <2.9% in low-to-middle income countries...
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Identification of biomarkers associated with the onset and progression of ketosis in transition dairy cows
DownloadFall 2016
Ketosis is a common metabolic disorder of transition dairy cows during the early lactation period. Cows with ketosis have lower milk yield and reproductive performance, greater risk of other periparturient diseases, and higher culling rate. Although ketosis has been extensively studied, not many...
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Investigating 14-3-3 Protein Subcellular Localization, Colocalization with Subcellular Markers and Interaction with Rac1
DownloadFall 2019
14-3-3 proteins are a group of widely expressed, highly conserved homo/heterodimeric acidic proteins. They usually bind to serine/threonine phosphorylated proteins, but also bind to proteins in a phosphorylation-independent manner. 14-3-3 proteins have over 200 binding partners. 14-3-3 proteins...
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Fall 2013
Plakoglobin (γ-catenin) is a member of the Armadillo family of proteins and a homolog of β-catenin with similar dual adhesive and signaling functions. The adhesive function of these proteins is mediated by their interactions with cadherins and their signaling function by association with various...
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Fall 2015
Despite considerable research progress towards characterizing the neurobiology of anxiety, the focus on putative behavioral markers and the absence of a common behavioural/neurobiological signature for the different classes of anxiolytic drugs have potentially slowed research into the neural...
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Spring 2018
The presence of natural oil seeps, abandoned well sites (generally containing light oil), and high quality source rocks along the coast of western Newfoundland has refocused interest on the region as an area for potential petroleum exploration and development. Most of the oil seeps and old well...