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Skip to Search Results- 1Arkell, Nicholas P
- 1Bell, Wayne Ronald Victor
- 1Chisholm, Roderick A.
- 1Cui, Xin
- 1Dewar, Matthew P
- 1Engelhardt, Daniel
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Development and Application of Protected Amino Acids for the Installation of Stable Post-translational Modifications Using Solid-Phase Peptide Synthesis
DownloadFall 2022
This thesis describes the synthesis of non-canonical amino acid building blocks and their use in solid-phase peptide synthesis (SPPS) to explore peptidic drug analogues based on natural products. We replaced sensitive functionalities found in the structure of naturally produced peptides with...
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Fall 2019
Carboxylic acids are a ubiquitous class of molecules in the field of organic chemistry and represent versatile building blocks in synthetic chemistry. Methods that enable the formation of new carbon–carbon or carbon–heteroatom bonds from carboxylic acids via the extrusion of carbon dioxide can...
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Spring 2012
The study of heterobimetallic complexes (having two different metal atoms) involves combining the unique properties of each metal, which can give rise to interesting contrasts in reactivity compared to either metal alone. With two different metals incorporated into one complex, a more diverse...
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Earth-Abundant Transition Metal Hydride Complexes for Dehydrocoupling and Hydrosilylation Catalysis
DownloadFall 2015
The research presented in this thesis details the synthesis of transition metal hydride complexes, with the focus on utilising these complexes for (a) the dehydrocoupling of amine-borane adducts, and (b) the hydrosilylation and hydroboration of unsaturated organic moieties. In both instances,...
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Exploration of Microscopic Structure and Dynamics in Halide Perovskite and Perovskite−Inspired Materials with Solid-State NMR Spectroscopy
DownloadSpring 2022
The work presented in this thesis describes the synthesis, structure, and optical properties of three different classes of halide-based perovskite materials, namely, metal halide perovskites of ABX3 type, halide double perovskites of A2B'B"X6 type, and “vacancy-ordered perovskites” of A2BX6 type...
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Exploring Atomic Force Microscopy To Probe Charge Transport Through Molecular Films And For The Development Of Combinatorial Force Microscopy
DownloadFall 2012
Since the invention of the atomic force microscope (AFM), this technology has had profound implications in the study of material science and molecular biology. The ability to visualize and perform quantitative analysis of the nanoscale properties of surfaces has provided great insights into...
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Spring 2018
Due to the natural heterogeneity of rock there exists a large variance between samples in geomechanical engineering testing. Additionally, the number of samples available for testing that meet the screening requirements for grain size, mineralogy, bedding orientation and moisture content can...
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Spring 2022
Phage display libraries bearing natural amino acids are commonly used for discovering potential therapeutic macrocycles; however, direct application of those linear peptides often leads to poor pharmacokinetics, including low serum stability, lower cell membrane permeability, and rapid renal...
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Investigation of the Adsorption of Model and Oil Sands Process-Affected Water Naphthenic Acids on Graphite
DownloadSpring 2015
Naphthenic acids (NAs) are constituents of bitumen in the oil sands deposits in northern Alberta, Canada. The extraction process of bitumen creates an enormous amount of wastewater called oil sands process affected waters (OSPW). This OSPW contains elevated concentrations of NAs, and other...
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Investigation of the Synthesis, Reactivity and Biological Properties of Various 6-Substituted D-Fructose Derivatives
DownloadFall 2017
The detection of small tumors growing in complex organs, including breast tissue, is a challenge in modern medical imaging. The use of positron emission tomography (PET) and tracer molecules containing radionuclei such as 18F have been of significant value to detect small tumors. The commonly...