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Skip to Search Results- 2Gelozia, Shorena
- 1Cai, Fangze
- 1Hwang, Peter M.
- 1Li, Monica X.
- 1Lindert, Steffen
- 1Pineda-Sanbria, Sandra E.
- 1Calcium sensitizer
- 1Cardiac troponin activator
- 1Drug development
- 1Lewis acid
- 1Nazarov
- 1Nuclear magnetic resonance spectroscopy
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Spring 2019
The presence of complex polycyclic skeletons is a commonly encountered phenomenon in natural products and biologically active compounds. Having diverse synthetic approaches for accessing them is vital for the effective development of the pharmaceutical industry. Among other strategies, pericyclic...
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2016-01-01
Cai, Fangze, Li, Monica X., Pineda-Sanbria, Sandra E., Gelozia, Shorena, Lindert, Steffen, West, Frederick, Sykes, Brian D., Hwang, Peter M.
In cardiac and skeletal muscle, the troponin complex turns muscle contraction on and off in a calcium-dependent manner. Many small molecules are known to bind to the troponin complex to modulate its calcium binding affinity, and this may be useful in a broad range of conditions in which striated...