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2010

Clawson,M. L., Wang, Z., Stothard, P., McKay, S., Laegreid, W. W., Williams J. L., Murdoch, B. M., Settles, M., Moore, S. S., Prasad, A.

Background Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease that is invariably fatal in cattle and has been implicated as a significant human health risk. Polymorphisms that alter the prion protein of sheep or humans have been associated with variations in...

2007

Stothard, P., Wang, Z., de Givry, S., Marques, E., Moore, S. S., Womack, J., Murdoch, B.

Background Radiation hybrid (RH) maps are considered to be a tool of choice for fine mapping closely linked loci, considering that the resolution of linkage maps is determined by the number of informative meiosis and recombination events which may require very large mapping populations....

2008

Grant, J. R., Moore, S. S., Xiu, Z., Murdoch, B. M., Kolbehdari, D., Stothard, P., Wang, Z., Prasad, A., Marques, E.

Genetic improvement of livestock populations can be achieved through detection and mapping of genetic markers linked to quantitative trait loci (QTL). With the completion of the bovine genome sequence assembly, single nucleotide polymorphism (SNP) assays spanning the whole bovine genome and...

2011

Plastow, G., Durunna, O. N., Stothard, P., Mujibi, F. D. N., Moore, S. S., Wang, Z., Basarab, J. A., Nkrumah, D. J., Crews Jr, D. H., Mah, J.

The benefit of using genomic breeding values (GEBV) in predicting ADG, DMI, and residual feed intake for an admixed population was investigated. Phenotypic data consisting of individual daily feed intake measurements for 721 beef cattle steers tested over 5 yr was available for analysis. The...

2008

Schnabel, R. D., Wang, Z., Taylor, J. F., Gill, C. A., Van Tassell, C. P., Gao, C., Aerts, J., Williams, J. L., Neto, E. D., Murdoch, B. M., Matukumalli, L. K., Coppieters, W., McKay, S. D., Mannenl, H., Crews, D., Moore, S. S.

Background Analyses of population structure and breed diversity have provided insight into the origin and evolution of cattle. Previously, these studies have used a low density of microsatellite markers, however, with the large number of single nucleotide polymorphism markers that are now...

2004

Hansen, C., Murdoch, B., Guercio, S., Basarab, J. B., Moore, S. S., Meng, Y., Li, C., Nkrumah, J. D.

Leptin is a 16-kDa-hormone product of the obese gene synthesized and expressed predominantly by adipose tissues, which has been shown to play major roles in the regulation of body weight, feed intake, energy balance, fertility, and immune system functions. We report an investigation into the...

2005

Stothard, P., Van Domselaar, G., Cruz, J., Wishart, D.S., Shrivistava, S., Guo, A.C., O'Neill, B., Ellison, M.J.

BacMap is an interactive visual database containing fully labeled, zoomable and searchable chromosome maps from more than 170 bacterial (archaebacterial and eubacterial) species. It uses a recently developed visualization tool (CGView) to generate highresolution circular genome maps from sequence...

2005

Stothard, P., Lu, P., Cruz, J.A., Szafron, D., Van Domselaar, G.H., Shrivistava, S., Guo, A., Dong, X., Grenier, R., Wishart, D.S.

BASys (Bacterial Annotation System) is a web server that supports automated, in-depth annotation of bacterial genomic (chromosomal and plasmid) sequences. It accepts raw DNA sequence data and an optional list of gene identification information and provides extensive textual annotation and...

2013

Karisa, B. K., Bruce, H. L., Plastow, G. S., Moore, S. S., Thomson, J., Wang, Z.

The objective of this study was to use the candidate gene approach to identify the genes associated with carcass quality traits in beef cattle steers at the University of Alberta Ranch at Kinsella, Canada. This approach involved identifying positional candidate genes and prioritizing them...

2010

Jin, W., Guan, L., Dodson, M. V., Basarab, J. A., Moore, S. S.

Background MicroRNAs (miRNAs), a family of small non-coding RNA molecules, appear to regulate animal lipid metabolism and preadipocyte conversion to form lipid-assimilating adipocytes (i.e. adipogenesis). However, no miRNA to date has been reported to modulate adipogenesis and lipid deposition...