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Skip to Search Results- 38Field, Catherine J.
- 8Sawyer, Michael B.
- 6Goruk, Susan
- 6Proctor, Spencer D.
- 6Ruth, Megan R.
- 5Prado, Carla M.
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Prophylactic ciprofloxacin treatment prevented high mortality, and modified systemic and intestinal immune function in tumour-bearing rats receiving dose-intensive CPT-11 chemotherapy
Download2009
Baracos, Vickie E., Xue, Hongyu, Sawyer, Michael B., Field, Catherine J
Infectious complications are a major cause of morbidity and mortality from dose-intensive cancer chemotherapy. In spite of the importance of intestinal bacteria translocation in these infections, information about the effect of high-dose chemotherapy on gut mucosal immunity is minimal. We studied...
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Protein Recommendation to Increase Muscle (PRIMe): Study protocol for a randomized controlled pilot trial investigating the feasibility of a high protein diet to halt loss of muscle mass in patients with colorectal cancer
Download2021-02-01
Ford, Katherine L., Sawyer, Michael B., Trottier, Claire F., Ghosh, Sunita, Deutz, Nicolaas E. P., Siervo, Mario, Porter Starr, Kathryn N., Bales, Connie W., Disi, Ilana Roitman, Prado, Carla M.
Background Severe muscle mass (MM) loss is a defining feature of cancer observed across all types and stages of disease and is an independent predictor of poor clinical outcomes including higher incidences of chemotherapy toxicity and decreased survival. Protein is essential to build MM, yet the...
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Representations of the health value of vitamin D supplementation in newspapers and magazines: Media content analysis
Download2014
Field, Catherine J., McCormack, James P., Caulfield, Timothy, Rachul, Christen, Clark, Marianne
Objective To examine the nature of media coverage of vitamin D in relation to its role in health and the need for supplements. Design Media content analysis. Setting Print articles from elite newspapers in the UK, the USA and Canada. Participants 294 print newspaper articles appearing over...
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Single and combined supplementation of glutamine and n-3 polyunsaturated fatty acids on host tolerance and tumour response to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11)/5-fluorouracil chemotherapy in rats bearing Ward colon tumour
Download2009
Xue, Hongyu, Sawyer, Michael B., Le Roy, Severine, Dieleman, Levinus A., Baracos, Vickie E., Field, Catherine J.
Prior reports suggest that during irinotecan (7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin; CPT-11) chemotherapy in laboratory rats, the anti-tumour efficacy and diarrhoea toxicity could be modulated by n-3 PUFA and glutamine, respectively. We further examined how these two...
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Skeletal muscle anabolism is a side effect of therapy with the MEK inhibitor: Selumetinib in patients with cholangiocarcinoma
Download2012
Ghosh, Sunita, Doyle, L. Austin, Baracos, Vickie E., Prado, Carla M., Sawyer, Michael B., Bekaii-Saab, Tanios, Shrestha, Suraj
background: Cancer cachexia is characterised by skeletal muscle wasting; however, potential for muscle anabolism in patients with advanced cancer is unproven. methods: Quantitative analysis of computed tomography images for loss/gain of muscle in cholangiocarcinoma patients receiving selumetinib...
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Systematic review of safety and tolerability of a complex micronutrient formula used in mental health
Download2011
Simpson, J. Steven A., Crawford, Susan G., Kaplan, Bonnie J., Field, Catherine J., Burgess, Ellen, Goldstein, Estelle T.
Background Theoretically, consumption of complex, multinutrient formulations of vitamins and minerals should be safe, as most preparations contain primarily the nutrients that have been in the human diet for millennia, and at safe levels as defined by the Dietary Reference Intakes. However, the...
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The current recommended vitamin D intake guideline for diet and supplements during pregnancy is not adequate to achieve vitamin D sufficiency for most pregnant women
Download2016
Maggiore, Jack A., Eliasziw, Misha, Rabi, Doreen, O'Beirne, Maeve, Field, Catherine J., Hanley, David A., Dewey, Deborah, Aghajafari, Fariba, Weinberg, Amy, Kaplan, Bonnie J., Ross, Sue
Background The aims of this study were to determine if pregnant women consumed the recommended vitamin D through diet alone or through diet and supplements, and if they achieved the current reference range vitamin D status when their reported dietary intake met the current recommendations....
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2013
Ruth, Megan R., Field, Catherine J.
The intestine and the gut-associated lymphoid tissue (GALT) are essential components of whole body immune defense, protecting the body from foreign antigens and pathogens, while allowing tolerance to commensal bacteria and dietary antigens. The requirement for protein to support the immune system...
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The modifying effects of galactomannan of Canadian-grown fenugreek (Trigonella foenum-graecum L) on the glycemic and lipidemic staus in rats
Download2008-01-01
Srichamroen, Achalee, Field, Catherine J., Thomson, Alan B., Basu, Tapan K.
Using high sucrose-fed male Sprague-Dawley rats, a study was conducted to determine the effects of feeding Galactomannan (GAL), a soluble dietary fiber extracted from Canadian-grown fenugreek seeds, on blood lipid and glucose responses. Rats (n = 8, 175–200 g) were randomly assigned to one of...
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The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats
Download2014
Baracos, Vickie, Dieleman, Levinus, Farhangfar, Arazm, Lin, Xiaoxi B., Gänzle, Michael G., Sawyer, Michael B., Valcheva, Rosica, Schieber, Andreas
CPT-11 is a drug used as chemotherapy for colorectal cancer. CPT-11 causes toxic side-effects in patients. CPT-11 toxicity has been attributed to the activity of intestinal microbiota, however, intestinal microbiota may also have protective effects in CP!-11 chemotherapy. This study aimed to...