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2011

Willing, Benjamin P., Finlay, B. Brett , Thanachayanont, Teerawat, Croxen, Matthew, Vacharaksa, Anjalee

Host resistance to bacterial infections is thought to be dictated by host genetic factors. Infections by the natural murine enteric pathogen Citrobacter rodentium (used as a model of human enteropathogenic and enterohaemorrhagic E. coli infections) vary between mice strains, from mild...

2007

Gerdts, Volker, Meurens, Francois, Willing, Benjamin P., Berri, Mustapha, Siggers, Richard H., Van Kessel, Andrew G., Salmon, Henri

Background CCL25/TECK and CCL28/MEC are CC chemokines primarily expressed in thymic dendritic cells and mucosal epithelial cells. Their receptors, CCR9 and CCR10, are mainly expressed on T and B lymphocytes. In human, mouse, pig and sheep CCL25 and CCL28 play an important role in the segregation...

2015

Borchers, Christoph H., Willing, Benjamin P., Sansonetti, Philippe J., Uhrig, Marco, Vonaesch, Pascale, Reynolds, Lisa A., Scholz, Roland, Wlodarska, Marta, Partida, Oswaldo, & Finlay, B. Brett, Brown, Eric M., Han, Jun, Arrieta, Marie-Claire

Environmental enteropathy (EE) is a subclinical chronic inflammatory disease of the small intestine and has a profound impact on the persistence of childhood malnutrition worldwide. However, the aetiology of the disease remains unknown and no animal model exists to date, the creation of which...

2020-07-22

Munyaka, Peris M., Blanc, Fany, Estelle, Jordi, Lemonnier, Gaetan, Leplat, Jean-Jacques, Rossignol, Marie-Noelle, Jardet, Deborah, Plastow, Graham, Billon, Yvon, Willing, Benjamin P., Rogel-Gaillard, Claire

The gut microbiota comprises a large and diverse community of bacteria that play a significant role in swine health. Indeed, there is a tight association between the enteric immune system and the overall composition and richness of the microbiota, which is key in the induction, training and...

2009-01-01

Thacker, Philip A., Haq, Inam, Willing, Benjamin P., Leytem, April B.

A total of 240 day-old broiler chicks were used to study the effects of phytase on performance and phosphorus (P) excretion from birds fed diets containing low phytate barleys formulated without inorganic P. A positive control based on Harrington barley (HB) was formulated to meet requirements...

2019-01-01

Diether, Natalie E., Willing, Benjamin P.

Protein fermentation by gut microbiota contributes significantly to the metabolite pool in the large intestine and may contribute to host amino acid balance. However, we have a limited understanding of the role that proteolytic metabolites have, both in the gut and in systemic circulation. A...

2019-01-01

Fouhse, Janelle M., Yang, Kaiyuan, More-Bayona, Juan, Gao, Yanhua, Goruk, Susan, Plastow, Graham, Field, Catherine J., Barreda, Daniel R., Willing, Benjamin P.

Antibiotic exposure during neonatal development may result in transient or persistent alterations of key microbes that are vital for normal development of local and systemic immunity, potentially impairing immune competence later in life. To further elucidate the relationship between antibiotic...

2012

Hartmann, Martin, Sekirov, Inna, Finlay, B. Brett, Al-Zahrani, Fatimah, Willing, Benjamin P., Ferreira, Rosana B. R., Gill, Navkiran, Antunes, L. Caetano M.

The intestinal microbiota has been found to play a central role in the colonization of Salmonella enterica serovar Typhimurium in the gastrointestinal tract. In this study, we present a novel process through which Salmonella benefit from inflammatory induced changes in the microbiota in order to...

2020-10-11

Amat, Samat, Lantz, Hannah, Munyaka, Peris M., Willing, Benjamin P.

A diverse and dynamic microbial community (known as microbiota) resides within the pig gastrointestinal tract (GIT). The microbiota contributes to host health and performance by mediating nutrient metabolism, stimulating the immune system, and providing colonization resistance against pathogens....

2016

Denamur, Erick, Tourret, Jérôme, Dion, Sara, Willing, Benjamin P., Wachtel, Sarah, Finlay, B. Brett, Dufour, Nicolas, Croxen, Matthew A.

Uropathogenic Escherichia coli (UPEC) strains live as commensals in the digestive tract of the host, but they can also initiate urinary tract infections. The aim of this work was to determine how a host detects the presence of a new UPEC strain in the digestive tract. Mice were orally challenged...