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Fall 2014

Klute, Mary J.

This thesis is on peroxisome evolution and reports my findings with regard to two major aspects of this process. First, I investigated the evolution of a peroxisomal protein family for which large expansions had been noted in diverse eukaryotes from a comparative genomic perspective and combined...

Spring 2011

Virk, Maninder

Peroxisomes are single-membrane-bound ubiquitous organelles required for several important metabolic pathways like lipid metabolism and peroxide detoxification. They are indispensable for normal human development, because lack of metabolically functional peroxisomes causes fatal peroxisome...

Spring 2015

Northrup, Victoria A.

Mutations in the mitochondrial genome (mtDNA) have been linked to a wide variety of disorders. mtDNA analyses require large starting samples and are complicated by the presence of nuclear mitochondrial pseudogenes (NUMTs), which can cause false positives in PCR-based approaches. Microfluidic...

Fall 2010

Chang, Jinlan

Peroxisomes are indispensable organelles that perform many essential metabolic activities. Thus, eukaryotic cells have evolved molecular mechanisms to ensure the inheritance of peroxisomes from mother cell to daughter cell at cell division. In the budding yeast Saccharomyces cerevisiae, the class...

Spring 2013

Lancaster, David L

Prions are infectious proteins. In their prion conformation, they catalyze the transformation of non-prion isomers into prions. Another characteristic common to currently identified prions is that they form amyloid aggregates. They occur in several mammals and multiple species of yeast, acting in...