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Spring 2019
Higher vertebrates share multiple mechanisms of immune defences; however, evolutionarily divergent species display unique characteristics to achieve immunity. Although significant knowledge regarding acute inflammation comes from studies in classical models, understanding of distinct immune...
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Fall 2012
Teleosts rely on innate immunity to protect themselves from pathogens. Colony stimulating factor-1 (CSF-1) and its cognate receptor CSF-1R control survival, proliferation, differentiation and function of macrophages. Recently, a novel soluble form of CSF-1R (sCSF-1R) was identified in goldfish....
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Fall 2017
Since antiquity, fever has been documented as a physiological response to infection characterized by an increase in body temperature. Though fever is commonly regarded as a deleterious symptom of inflammation and is often suppressed using NSAID drugs, little is known about the effects that fever...
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Fall 2017
The inflammatory response is a complex biological process initiated following the recognition of noxious stimuli. It is composed of an elaborate cascade of both pro- and anti-inflammatory mediators, essential for effective defenses against infection, the removal of damaged cells, and the...
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Fall 2016
Transferrin is an evolutionary conserved protein that in addition to having a critical role in iron transport also has been shown to have a crucial role in host defence. Transferrin has been shown to sequester iron from invading pathogens, act directly against microbial pathogens, and is an...