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Spring 2023
Prion diseases are rare, inexorably progressive, and fatal neurodegenerative disorders, with no therapy other than palliation. The key event in the pathogenesis of prion diseases is the conformational conversion of the cell-surface glycoprotein (PrPC), from a predominantly α-helical structure...
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Spring 2023
Prion diseases are rare and fatal neurodegenerative disorders caused by the misfolding of the cellular prion protein (PrPC) to its infectious form (PrPSc). Until recently, the structure of PrPSc was a subject of much debate as there is evidence to support both the 4-rung β-solenoid model and...
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Fall 2022
Prion diseases are neurodegenerative disorders that arise from the misfolding of the cellular prion protein (PrPC) into the infectious prion protein (PrPSc), resulting in a conformational change in the protein structure. Despite being extensively studied, high-resolution structural information...
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Fall 2020
Tauopathies are a class of neurological disorders associated with the aggregation of the tau protein into neurofibrillary tangles. The most prominent tauopathy is Alzheimer’s disease (AD), which presents as two forms: early onset (familial, fAD) and late onset (sporadic, sAD). sAD does not have a...
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Fall 2023
Prion diseases are a group of deadly neurological disorders caused by the abnormal folding of the prion protein into an infectious form known as PrPSc. Chronic wasting disease is a prion disease affecting cervids such as deer, elk, moose, and reindeer. Despite ongoing efforts to understand prion...