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Skip to Search Results- 1Aujla, Preetinder K
- 1Chute, Michael
- 1Kandalam, Vijay S.
- 1Kilic, Tolga
- 1Lee, Ji Won
- 1Shen, Mengcheng
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Fall 2022
Menisci are fibrocartilaginous structures of the knee that function in mechanical load transmission to protect articular cartilage from forces that may initiate osteoarthritic changes. A population of cells responsible for regulating the tissues’ biomechanical properties are meniscus...
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Spring 2014
With matrix metalloproteinases-2 (MMP2) deficiency, we observed thoracic aortic aneurysm in 70% of MMP2-/- mice but no abdominal aortic aneurysm following four weeks of angiotensin II (Ang II) infusion. We found markedly suppressed recoil properties in the thoracic aorta of MMP2-/-- Ang II mice....
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Exploring the Role of ADAM17 in Vascular Smooth Muscle Cells and Macrophages Within the Atherosclerotic Plaque
DownloadSpring 2024
Atherosclerosis, characterized by arterial fat deposits, is the root cause of many cardiovascular diseases. Plaque deposition results from a series of events initiated by elevated plasma cholesterol, inflammation of the arterial wall, cholesterol uptake, macrophage-derived foam cell formation,...
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Role of A Disintegrin and Metalloproteinases (ADAMs)- 15 and 17 in Cardiac Remodelling Following Pressure Overload
DownloadSpring 2024
Myocardial remodeling is a critical process in response to cardiac stress or injury, which includes changes in the cardiomyocyte size, the extracellular matrix (ECM), and cell-ECM interactions. Cardiac hypertrophy is the morphological increase in the myocardial mass by an increase in the...
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Role of Disintegrin and Metalloproteinase 17 (ADAM17) in Hypertension and Thoracic Aortic Aneurysm
DownloadFall 2018
Hypertension is a major risk factor for cardiovascular complications such as stroke, myocardial infarction, heart failure, and renal failure, and therefore is an enormous healthcare burden worldwide. The renin-angiotensin system (RAS) is an essential regulator of blood pressure homeostasis, and...
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Spring 2021
Ischemic cardiomyopathy remains the primary cause of heart failure worldwide. A disintegrin and metalloproteinases (ADAMs) are a family of membrane-bound proteases with diverse functions. ADAM15 is expressed in the myocardium and is involved in mechanisms associated with ischemic heart disease...
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Fall 2012
Heart disease is a leading cause of morbidity and mortality in the world with a growing prevalence in a variety of manifestations. Many of the events that occur in the heart during the progression of disease have been explored to identify a causative mechanism to develop effective treatments and...