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Skip to Search Results- 2Jutras, Jean-David
- 2Yip, Eugene
- 1Abdou, Ismail
- 1Adamia, Sophia
- 1Alaee, Mahsa
- 1Anderson, Danielle L.
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Evaluation of Phosphatidylserine-Binding Peptides Radiolabeled with Fluorine 18 for in vivo Imaging of Apoptosis
DownloadSpring 2012
We currently do not have a clinical method to directly assess apoptosis induced by cancer therapies. Phosphatidylserine (PS) is an attractive target for imaging apoptosis since it is on the exterior of the apoptotic cells and PS externalization is an early marker of apoptosis. PS-binding peptides...
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Evaluation of selective cyclooxygenase-2 (COX-2) inhibitors as radiosensitizing agents for cancer therapy
DownloadFall 2014
Tumour resistance to chemo- and radiotherapy often prevents successful cancer therapy. This has promoted the search for novel agents that target specific molecular pathways linked to tumour resistance to cancer therapy. Among these novel agents are inhibitors of the inducible isoform of the...
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Evaluation of the Advanced Collapsed-cone Engine for High Dose Rate Ir-192 GYN and Scalp Brachytherapy
DownloadSpring 2017
Standard treatment planning in brachytherapy (BT) uses the well-accepted TG-43 dose calculation formalism, which does not account for tissue or material heterogeneities. However, recent developments in BT have led to commercial treatment planning systems (TPSs) using model based dose calculation...
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Exploiting the Enhanced Permeability and Retention Effect for the Targeting of Tumors with 18F-SiFA Polymer Nanoparticles
DownloadFall 2017
Over the last several decades great progress has been made in cancer diagnosis and detection. One foundation of this progress has been improved imaging technologies. Among the most promising imaging technologies for cancer detection is Positron Emission Tomography (PET). PET imaging allows for...
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Fall 2010
Breast cancer is the most common cancer and the leading cause of cancer-related death among Canadian women. Despite improvements in treatment and early detection, there is still a need to develop novel therapies for breast cancer management. Aberrant Notch signaling is tumorigenic and is...
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Spring 2012
The conventional region-of-interest (ROI) method to evaluate dynamic Positron Emission Tomography (PET) images can be complex, time consuming, inaccurate (e.g. partial volume effect), and operator-dependent. To overcome these problems, an optimization-based factor analysis of dynamic structures...
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Fat Unsaturation Quantification, Including ω-3 Measures, with In-Vivo Magnetic Resonance Spectroscopy
DownloadSpring 2021
Fat composition is relevant to disease and can be assessed non-invasively using Magnetic Resonance Spectroscopy (MRS). MRS studies do not usually account for the ω-3 (omega-3) fat content because of its low prevalence in human adipose tissue (≈ 1 %) and because the ω-3 (≈ 1.0 ppm) and non-ω-3 (≈...
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Spring 2019
Cancer remains a challenging disease to tackle. The heterogeneity and evolution of the disease necessitates the development of diverse approaches to treat cancer. In this thesis, two different approaches have been undertaken to address this issue. The first aim was to activate the master tumor...
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Fall 2015
DEAD box proteins are a family of RNA helicases implicated in every aspect of RNA biogenesis and metabolism. Modification of RNA secondary structure by DEAD box proteins has widespread effects on numerous cellular processes due to the ubiquitous nature of RNA. While the biochemical activity of...