Search
Skip to Search Results- 2Jutras, Jean-David
- 2Yip, Eugene
- 1Abdou, Ismail
- 1Adamia, Sophia
- 1Alaee, Mahsa
- 1Anderson, Danielle L.
-
Spring 2022
Radioisotopes of scandium have been proposed as potential candidates for radiotheranostics, the combination of targeted imaging and therapy of cancer. Radiolabelling specific targeting vectors with positron emitting radioisotopes (43Sc, 44Sc) provides a quantitative measure of the disease through...
-
Deletion of F4L (ribonucleotide reductase) in Vaccinia Virus Produces a Selective Oncolytic Virus and Promotes Anti-tumor Immunity with Superior Safety in Bladder Cancer
DownloadFall 2017
Overall recurrence of non-muscle-invasive bladder cancer (NMIBC) can be as high as 80% within 5 years of initial treatment. High-grade NMIBC has the greatest risk of recurrence and treatment for these patients includes surgery followed by intravesical therapy with the immunotherapeutic agent...
-
Design and simulation of a short, 10 MV, variable energy linear accelerator for use in linac-MR systems
DownloadFall 2016
Hybrid linac-MR devices are currently being designed and constructed by several groups around the world which combine a linear accelerator with an MRI in order to enable real-time 3D imaging to visualize tumor movement during external beam radiotherapy treatments. Each of the current systems is...
-
Spring 2013
Chromatin plays a pivotal role in regulating critical DNA dependent processes, such as transcription. Chromatin and associated epigenetic modifications form the molecular basis of differentiation and development and are misregulated in disease states, such as cancer. Histone H1 molecules are key...
-
Development of a Targeted Adenoviral Vector Expressing HSV-TK for use in Breast Cancer Gene Therapy and Analysis through Positron Emission Tomography
DownloadFall 2012
While adenoviral (Ad) vectors are the most commonly used gene delivery vector for human gene therapy, improvements must be made to increase Ad specificity to tumors if they are to be used for cancer gene therapy. Our goal is to target adenoviral vectors to breast cancer (BrCa) cells to induce...
-
Development of an Efficient Algorithmic Framework for Deterministic Patient Dose Calculation in MRI-guided Radiotherapy
DownloadSpring 2020
Accurate and efficient patient dose calculation for Magnetic Resonance Imaging (MRI)-guided Radiotherapy is pursued based on a deterministic solution to the Linear Boltzmann Transport Equation (LBTE) with magnetic fields, as a technique which does not suffer from statistical uncertainty, and...
-
Development of Genetic Medicines for the Treatment and Prevention of Infectious Disease, Cancer, and Aging
DownloadSpring 2022
Gene therapy has potential to become the Holy Grail of modern medicine, however, its clinical success has been hindered due to the lack of a safe and effective nucleic acid delivery platform. The recent success of non-viral RNA delivery platforms has revitalized the field and spurred great...
-
Development of novel compounds for the molecular imaging of hypoxia: 18F-labeled nitroimidazoles and hypoxia inducible factor 1 alpha (HIF-1a)-targeting compounds
DownloadSpring 2023
Imaging of hypoxia has been previously achieved using positron emission tomography (PET) with radiotracers such as [18F]fluoroazomycin arabinoside ([18F]FAZA) [1] or [18F]fluoromisonidazole ([18F]FMISO) [2]. These typical nitroimidazole containing compounds are reductively trapped in hypoxic...
-
Fall 2014
DEAD box protein 1 (DDX1) is a member of the DEAD box family of helicases which bind and unwind double-strand (ds) RNA and are associated with all aspects of RNA metabolism. DDX1 was identified by differential screening of a subtracted cDNA library prepared from two retinoblastoma (RB) cell...