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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Airo, Adriana M
- 1Arendt, Christopher William.
- 1Awadh, Abdullah
- 1Azaizeh, Bara'ah
- 1Bacik, John-Paul
- 8Evans, David (Medical Microbiology and Immunology)
- 6Foley, Edan (Medical Microbiology and Immunology)
- 5Barry, Michele (Medical Microbiology and Immunology)
- 5Ingham, Robert (Medical Microbiology and Immunology)
- 5Ostergaard, Hanne (Medical Microbiology and Immunology)
- 3Baldwin, Troy (Medical Microbiology and Immunology)
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Examination of the Regulation of Phosphorylation Events in Macrophage Adhesion and Response to Zymosan
DownloadFall 2012
Macrophages play a central role in innate immunity, most notably in tissue repair, phagocytosis of dead or infected cells, secretion of chemokine and cytokines at sites of infection, as well as the activation of other immune cells. These roles are highly dependent on their capacity to migrate...
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Examination of the roles of the AP-1 transcription factors, JunB and c-Jun, in the pathobiology of Anaplastic Lymphoma Kinase-positive, Anaplastic Large Cell Lymphoma (ALK+ ALCL)
DownloadSpring 2019
Anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) is an aggressive T cell lymphoma that is characterized by chromosomal translocations involving the gene encoding for the ALK tyrosine kinase. The ALK fusion proteins generated through these translocations initiate...
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Examining the origin of peripheral self-reactive T cells and the contribution of Gadd45beta to T cell selection events in the HYcd4 TCR transgenic mouse model
DownloadSpring 2014
Kelly, Stephanie Alicia Wilhelmina
Thymic negative selection is important for preventing self-reactive T cells from entering the circulation. However, some self-reactive T cell clones can escape negative selection and induce autoimmunity. The molecular pathways that regulate negative selection are currently unclear, but PD-1 and...
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Fall 2013
Proline-rich tyrosine kinase 2 (Pyk2) is a non-receptor protein tyrosine kinase that is highly expressed in hematopoietic cells. Our lab generated two polyclonal antibodies to investigate the regulation of Pyk2 in macrophages and T cells. In macrophages the N-terminal antibody immunoprecipitated...
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Spring 2016
Flaviviruses, such as West Nile virus (WNV), Powassan virus (POW), and Saint Louis encephalitis virus (SLEV), are significant pathogens capable of causing serious neurological disease in both humans and animals. Despite their relevance to human health, treatment and vaccines for these viruses...
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Exploration of methods for sequence based HLA typing and application to patients with hair dye allergy
DownloadFall 2011
Determining an individual’s spectrum of human leukocyte antigens (i.e. HLA type) by sequencing their HLA genes is known as sequenced-based typing (SBT). In the first part of this thesis, non-polymerase chain reaction (PCR) methods of achieving SBT were explored. HLA-DQ cDNA sequences were...