Search
Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Airo, Adriana M
- 1Arendt, Christopher William.
- 1Awadh, Abdullah
- 1Azaizeh, Bara'ah
- 1Bacik, John-Paul
- 8Evans, David (Medical Microbiology and Immunology)
- 6Foley, Edan (Medical Microbiology and Immunology)
- 5Barry, Michele (Medical Microbiology and Immunology)
- 5Ingham, Robert (Medical Microbiology and Immunology)
- 5Ostergaard, Hanne (Medical Microbiology and Immunology)
- 3Baldwin, Troy (Medical Microbiology and Immunology)
-
Fall 2014
Viral entry is an attractive antiviral target. Entry inhibitors prevent infection of healthy cells and inhibit viral replication before viruses establish persistent reservoirs. Two entry steps, the primary attachment to cellular glycans and the lipid rearrangements during fusion, are conserved...
-
Fall 2015
Many cellular processes are regulated by the ubiquitin proteasome system (UPS), which utilizes the polypeptide ubiquitin to mark proteins for destruction via the 26S proteasome. Since the UPS plays an important role in cellular homeostasis, many viruses have evolved strategies to regulate the...
-
Characterizing tolerance in CD8 T cells in the absence of Bim-mediated clonal deletion to tissue restricted antigens
DownloadFall 2016
T cells are part of the adaptive immune system that eliminate pathogen-infected cells, but do not harm healthy cells. Precursor T cells, termed thymocytes, develop in the thymus where they randomly generate and express unique antigen specific T cell receptors (TCR) during the CD4+CD8+ double...
-
Clinical impact of submicroscopic malaria on delivery outcomes and the role of VAR2CSA antibodies in pregnant women from Colombia
DownloadFall 2018
Malaria caused by the genus Plasmodium (P.) is one of the oldest and most important parasitic infections globally. Pregnant women are at an increased risk for malaria, where the disease poses a significant risk to both maternal and child health. Better diagnosis of malaria can have an immediate...
-
CNS Inflammasome Activation and Pyroptosis in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
DownloadFall 2019
McKenzie, Brienne Alexandra Furfaro
Multiple sclerosis (MS) is a progressive and incurable demyelinating disease of the central nervous system (CNS). The neuropathogenesis of MS and its prototypic animal model, experimental autoimmune encephalomyelitis (EAE), is defined by persistent neuroinflammation, involving the activation of...
-
Spring 2013
The adaptive immune response against intracellular pathogens is largely mediated by CD8+ T lymphocytes. The clonal expansion and expression of cytolytic and immune stimulatory proteins by CD8+ T cells is responsible for their protective immune function. Prior to exhibiting effector activity,...
-
Spring 2019
Vibrio cholerae is a diverse bacterial species that causes a wide range of disease,ranging from the diarrheal disease cholera by toxigenic strains to mild gastroenteritiscaused by non-toxigenic strains. Toxigenic strains are able to cause more severe diseasedue to the secretion of cholera toxin....