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Skip to Search Results- 8El-Kadi, Ayman (Faculty of Pharmacy and Pharmaceutical Sciences)
- 6Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Barakat, Khaled (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Brocks, Dion R. (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Seubert, John (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Abukhashim, Mohamed
- 1Alma'ayah, Zaid H
- 1Alshamsan, Aws
- 1Althurwi, Hassan N
- 1Asiri, Abdulrahman Y
- 1Binkhathlan, Ziyad
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Fall 2017
The voltage-gated KCNQ1/KCNE1 potassium ion channel plays a key role in maintaining the heart rhythm. An active channel generates the slow delayed rectifier (IKs) current in the heart. Both loss-of-function and gain-of-function mutations in KCNQ1 or KCNE1 are linked to many heart-related...
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Delivery of STAT3 inhibitor cucurbitacins to tumor by polymeric nano-carriers : Implications in cancer chemo- and immunotherapy
DownloadFall 2009
Signal Transducer and Activator of Transcription 3 (STAT3), a common oncogenic mediator, is constitutively activated in many types of human cancers and plays a critical role in tumor growth and cancer immune evasion. The focus of this dissertation is the delivery of STAT3 inhibitor cucurbitacins...
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Development of block copolymer based nanocarriers for the solubilization and delivery of valspodar
DownloadFall 2011
One of the major causes of failure in cancer chemotherapy is multidrug resistance (MDR), where cancer cells become resistant to different types of anticancer drugs. Over-expression of membrane efflux pumps like P-glycoprotein (P-gp), which recognizes different chemotherapeutic agents and...
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Development of Poly(ethylene oxide)-block-poly(ε-caprolactone) based Micelles for Tumor Targeted Drug and siRNA Delivery
DownloadFall 2015
The use of nanotechnology has made significant advancements in cancer diagnosis and treatment. Polymeric micelles are a relatively new generation of nanocarriers mostly intended for the delivery of hydrophobic drugs. In this thesis, our objective was to develop an optimized polymeric micellar...
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Development of polymer and lipid based nano-delivery systems for targeted cancer chemotherapy
DownloadFall 2012
Conventional chemotherapy agents can kill tumor cells and inhibit tumor growth, but they produce severe side effects on normal cells at the same time. To shift the balance towards tumoral effects, it would be desirable to direct the anti-cancer drug towards tumor while restricting drug access to...
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Fall 2010
In many tumors, persistently-active signal transducer and activator of transcription 3 (STAT3) imparts several oncogenic features such as survival, proliferation, angiogenesis, and immune escape. Therefore, STAT3 targeting in cancer and cancer-exposed dendritic cells (DCs) is important for cancer...
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Fall 2015
Several studies have examined the toxic effects of individual aryl hydrocarbon receptor (AhR) ligands, yet there are relatively few reports of the combined toxic effects of AhR ligands and other environmental co-contaminants, such as heavy metals. Chromium (Cr+6) is one of the major environmental...
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MODULATION OF ARYL HYDROCARBON RECEPTOR (AHR)-REGULATED CARCINOGEN ACTIVATING ENZYMES BY ORGANIC ARSENICALS: A POTENTIAL THERAPEUTIC TARGET
DownloadSpring 2017
Arsenic is a worldwide environmental pollutant that is associated with skin and several types of internal cancers, such as liver, lung, kidney, urinary bladder, and prostate cancers. Recent reports revealed that organic arsenic metabolites, such as trimethylarsine oxide (TMAO), dimethylarsinic...
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PLGA-based nanoparticles for targeting of dendritic cells in cancer immunotherapy and immunomonitoring
DownloadSpring 2010
Cancer vaccines have shown little success in clinic. Dendritic cells (DCs) are of particular interest in cancer vaccination due to their role in cell-mediated immunity. Active targeting of DCs, through PLGA nanoparticles (PLGA-NPs) decorated with ligands for DC-expressed mannose receptor (MR) can...
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Role of cytochrome P450 (CYP) metabolites of arachidonic acid in the regulation of cAMP in HEK293 cells
DownloadFall 2011
Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs), which in turn are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). EETs are known to modulate a number of vascular and renal functions but the exact signaling...