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Skip to Search Results- 1Havixbeck, Jeffrey J
- 1Lund, Johanna M
- 1More Bayona, Juan
- 1Rieger, Aja M
- 1Sherif, Amro MS
- 1Trites, Michael
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Spring 2019
Higher vertebrates share multiple mechanisms of immune defences; however, evolutionarily divergent species display unique characteristics to achieve immunity. Although significant knowledge regarding acute inflammation comes from studies in classical models, understanding of distinct immune...
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Fall 2012
Teleosts rely on innate immunity to protect themselves from pathogens. Colony stimulating factor-1 (CSF-1) and its cognate receptor CSF-1R control survival, proliferation, differentiation and function of macrophages. Recently, a novel soluble form of CSF-1R (sCSF-1R) was identified in goldfish....
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Fall 2023
Fever is a physiological defense mechanism against infection associated with a rise in host’s temperature. Febrile responses are evolutionarily conserved through millions of years, taking place in both warm-blooded and cold-blooded vertebrates that share common biochemical pathways for fever...
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Fall 2014
Phagocytosis is an important, evolutionarily conserved mechanism integral to immune defense and homeostasis. Phagocytosis is initiated by the interaction of receptors on the surface of phagocytes with ligands on large particles, generally over 1 μm. Receptor ligation results in actin...
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Fall 2017
Since antiquity, fever has been documented as a physiological response to infection characterized by an increase in body temperature. Though fever is commonly regarded as a deleterious symptom of inflammation and is often suppressed using NSAID drugs, little is known about the effects that fever...
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Fall 2017
The inflammatory response is a complex biological process initiated following the recognition of noxious stimuli. It is composed of an elaborate cascade of both pro- and anti-inflammatory mediators, essential for effective defenses against infection, the removal of damaged cells, and the...
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Fall 2016
Transferrin is an evolutionary conserved protein that in addition to having a critical role in iron transport also has been shown to have a crucial role in host defence. Transferrin has been shown to sequester iron from invading pathogens, act directly against microbial pathogens, and is an...