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Skip to Search Results- 2Veldhoen, Richard
- 1ALSHUMAIMERI, NADA A.
- 1Acevedo Morantes, Claudia Y
- 1Aderibigbe, Ayodeji O.
- 1Ahsan, Irfan.
- 1Alabi, Adekunle
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Fall 2014
Multidrug resistant bacteria pose a threat to human health and economic burden for the healthcare system. Transmission of antibiotic resistance genes can occur by the conjugative transfer of the F plasmid between bacteria. The transferosome forms a channel linking the two cells together, while...
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Fall 2015
Calcium (Ca2+) ions serve a crucial role in numerous intracellular signaling pathways, controlling physiological functions as diverse as cell proliferation, immune system function, and muscular contraction. As such, the cell has evolved many different mechanisms to precisely control the movement...
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Insights into the Role of Choline Kinase in Endochondral Bone Formation and Human Osteoblasts Function
DownloadSpring 2014
Choline kinase (CK) phosphorylates choline to phosphocholine (PCho) and is the first enzyme in the CDP-choline pathway that generates phosphatidylcholine (PC). CK has three isoforms (CKα1, CKα2 and CKβ) that are encoded by two genes, Chkα and Chkb. Inactivation of Chkα results in embryonic...
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Insights into the role of CTP:phosphocholine cytidylyltransferase-alpha in hepatic lipid metabolism and cellular integrity
DownloadFall 2011
Lower levels of hepatic phosphatidylcholine (PC) are suggested to play a role in the pathogenesis of non-alcoholic steatohepatitis (NASH). Mice lacking hepatic CTP:phosphocholine cytidylyltransferase-α (LCTα-/-), the regulatory enzyme in the CDP-choline pathway for PC biosynthesis, were fed a...
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Insights into the Role of Phosphatidylethanolamine N-methyltransferase and the PC:PE Ratio in Liver Function
DownloadSpring 2019
PEMT is quantitatively important in the liver and is responsible for approximately 30% of hepatic PC synthesis, with the remaining 70% synthesized by the CDP-choline pathway. HFD-fed Pemt-/- mice and LPcyt1a-/- mice both develop NAFLD associated with reduced VLDL secretion and a reduced hepatic...
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Insights into the Transcriptional Regulation and Physiological Importance of Phosphatidylethanolamine N-Methyltransferase
DownloadSpring 2010
Phosphatidylcholine (PC) is made in all nucleated mammalian cells via the CDP-choline pathway. Another major pathway for PC biosynthesis in liver is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). We have identified 3T3-L1 adipocytes as a cell culture model that expresses PEMT...
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Fall 2020
Cellular responses to stress are an integral part of cardiovascular physiology and pathology, and endoplasmic reticulum (ER) stress is the key component in the development and progression of various heart diseases. However, the relative contribution of ER stress pathways to muscle damage and...
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Insulin signaling, mitochondrial DNA copy number regulation and aging in Caenorhabditis elegans
DownloadFall 2010
Mitochondrial dysfunction is considered as a key mechanism of aging but little is known about the impact of mitochondrial biogenesis. Mitochondrial DNA (mtDNA) copy number control is an important aspect of mitochondrial biogenesis and is highly regulated in eukaryotic organisms. By studying mtDNA...