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Fall 2021

Lee, Michelle

Ducks, as the natural reservoir host of influenza A virus (IAV), do not exhibit the same detrimental symptoms when infected by IAV as other susceptible host species, such as chickens and humans. A dysregulated NLRP3 inflammasome response activated by IAV has been linked to severe host outcomes,...

Spring 2022

Hisadomi, Satoko

Dairy cows often experience negative energy balance, fat mobilization and inflammation after calving, which increases health problems. Glutamate (Glu) is a primary energy source for the small intestine and a glucogenic amino acid in the liver, and feeding Glu enhances gastrointestinal growth,...

Fall 2024

Alzahrani, Khadija Rashed A

Lungs and airways health and protection depend on the integrity of airway epithelium. Insulin is a growth hormone that through activation of several signaling pathways play a central role to maintain cellular growth and activate metabolism. Airway epithelium is in constant exposure to inhaled...

Spring 2021

Sanaz Hatami

Normothermic ex-situ heart perfusion (ESHP) is an emergent technique that allows for continued perfusion of the beating heart, supplying required oxygen and nutrients. Also, this technique offers a venue to assess the metabolic and functional viability of the donated heart during the period of...

Fall 2018

Leimert, Kelycia

Birth is a complex biological event requiring genetic, cellular and physiological changes to the uterus, resulting in a uterus activated for completing the physiological processes of labour. We define the change from the state of pregnancy to the state of parturition as uterine transitioning,...

Spring 2019

Martin, Lisa

Introduction:Cancer-associated cachexia is defined as a multifactorial syndrome characterized by loss of body weight with specific losses of skeletal muscle and adipose tissue. Cachexia is driven by a variable combination of reduced food intake (FI) and distinct tumor-associated metabolic...

Fall 2019

Myung-chul Noh

Persistent hyperexcitability in the primary sensory afferents contributes substantially to the onset and the maintenance of neuropathic pain. Inteleukin-1β (IL-1β) has been implicated to directly interact with interleukin 1 receptor type I (IL-1RI) expressed in dorsal root ganglion (DRG) neurons...

Spring 2019

Perrott, Kevin M

Age is the single-most significant variable in the loss of normal tissue homeostasis resulting in degenerative disease. Increasing with age is a slight, but significant rise in pro-inflammatory factors in the absence of detectable infection, also known as “sterile inflammation”. Although the...

Fall 2023

Rusnak, Tianna

Obesity is a worldwide epidemic that is associated with immune dysfunction. In human and rodent models, obesity-induced immune dysfunction has been characterized by lower T cell proliferation and interleukin (IL)-2 production. While the mechanisms responsible for the observed reduction in T cell...

Fall 2022

Zare, Alaa

Inflammatory breast cancer (IBC) is a rare but aggressive type of breast cancer characterized by early and rapid metastasis leading to poor clinical outcomes. The tumor microenvironment (TME), including immune cells, fibroblasts and endothelial cells, has emerged as a major regulator of IBC...