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Skip to Search Results- 2In-Vivo
- 2Signal-Transduction
- 1Activation
- 1Cd22-Deficient Mice
- 1Cell Growth And Development
- 1Cultured-Cells
- 1Durum, Scott K.
- 1Ferris, Douglas K.
- 1Fisher, Robert J.
- 1Fliegel, Larry
- 1Kawasaki, N.
- 1Khaled, Annette R.
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Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22
2013
Pfrengle, F., Kawasaki, N., Paulson, J. C. , Macauley, M. S.
Differentiation of self from nonself is indispensable for maintaining B cell tolerance in peripheral tissues. CD22 and Siglec-G (sialic acid-binding Ig-like lectin G) are two inhibitory coreceptors of the BCR that are implicated in maintenance of tolerance to self Ags. Enforced ligation of CD22...
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Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization
Download2001-01-01
Khaled, Annette R., Moor, Andrea N., Li, Aiqun Q., Kim, Kyungjae, Ferris, Douglas K., Muegge, Kathrin, Fisher, Robert J., Fliegel, Larry, Durum, Scott K.
Trophic factor withdrawal induces cell death by mechanisms that are incompletely understood. Previously we reported that withdrawal of interleukin-7 (IL-7) or IL-3 produced a rapid intracellular alkalinization, disrupting mitochondrial metabolism and activating the death protein Bax. We now...