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Addressing the knowledge gaps in two common age-related conditions, both associated with nutrition and physical activity: Alzheimer’s Dementia and Sarcopenia
DownloadFall 2022
Background There is an aging demographic in many countries resulting in an increased prevalence of age-associated chronic disease, particularly Alzheimer's dementia [AD] and sarcopenia. Both conditions significantly impact independence. They also have other common effects on morbidity: Both...
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An exploration into the relationship of body composition parameters and survival outcomes in patients with resectable colorectal cancer
DownloadFall 2018
Both tumor biology and host-specific factors play an important role in the prognosis of colorectal cancer. Body composition is an emerging patient-specific factor, which is currently being elucidated. Opportunistic analysis of pre-existing staging computed tomography scans can be used to quantify...
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Elevated Fatty Acid Content in Muscle is Prevented by EPA and DHA in an Animal Model of Colorectal Cancer Receiving CPT-11 / 5-FU
DownloadFall 2012
This study aimed to assess the effect of irinotecan / 5-fluorouracil treatment on amount and types of fatty acids in skeletal muscles of tumor-bearing rats fed: a) control diet, b) fish oil diet. Rats bearing the Ward colorectal carcinoma were fed a semi-purified diet with or without fish oil...
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Exploring the Association Between Frailty and Adverse Clinical Outcomes in Inflammatory Bowel Disease
DownloadFall 2022
Background and Rationale: Chronological age does not always accurately reflect “biological age”, or the extent of physiological reserve an individual possesses to endure stressors. The concept of physiological reserve is best represented by frailty; a multifaceted syndrome or state that...
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Fall 2016
Adults with class II/III obesity (BMI ≥35 kg/m2) are at increased health risk, and may also present with lower lean mass in relation to excess adiposity, a condition termed sarcopenic obesity. A variety of body composition indices and cutpoints have been used to define this condition, mostly in...
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Sarcopenia is associated with clinical outcomes and physical function in children with end-stage liver disease pre-and-post liver transplantation
DownloadSpring 2020
Background & Aims: Sarcopenia is defined as reduced skeletal muscle mass (myopenia), muscle strength and physical performance. In adults with end stage liver disease (ESLD), sarcopenia is highly prevalent and associated with adverse outcomes. Emerging data have shown that sarcopenia is prevalent...