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Skip to Search Results- 4Amith, Schammim Ray
- 4Fliegel, Larry
- 2Baksh, Shairaz
- 2Wilkinson, Jodi Marie
- 1Benjaminy, Shelly
- 1Boukouris, Aristeidis
- 15Graduate and Postdoctoral Studies (GPS), Faculty of
- 15Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 4Biochemistry, Department of
- 4Biochemistry, Department of/Journal Articles (Biochemistry)
- 1Chemistry, Department of
- 1Chemistry, Department of/Journal Articles (Chemistry)
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Ganglioside Increases Metastatic Potential and Susceptibility of Prostate Cancer to Gene Therapy in vitro
DownloadFall 2009
Prostate cancer (CaP) is the 2nd most common cancer in North American men. Tumour management strategies are appropriate for early stage disease, but advanced disease has a poor prognosis and requires prompt treatment. Therefore, research into delay of tumour progression and efficacious treatment...
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Impact of conventional fractionated RT to pelvic lymph nodes and dose-escalated hypofractionated RT to prostate gland using IMRT treatment delivery in high-risk prostate cancer
DownloadFall 2009
Prostate cancer is the most common cancer among Canadian men. The standard treatment in high-risk category is radical radiation, with androgen suppression treatment (AST). Significant disease progression is reported despite this approach. Radiation dose escalation has been shown to improve...
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Mechanistic studies on the uptake and intracellular trafficking of DNA complexes in primary cells using lipid-modified cationic polymers as non-viral gene carrier
DownloadFall 2012
This thesis work is aimed at addressing some of the fundamental questions surrounding the intracellular fate of plasmid DNA in clinically-relevant primary cells, when delivered with lipid-modi!ed cationic polymers as gene carriers. We developed an optimized procedure for the transfection of...
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Ocular Gene Transfer in the Spotlight: Implications of Newspaper Content for Clinical Communications
Download2014-10-24
Bubela, Tania, Benjaminy, Shelly
Background Ocular gene transfer clinical trials are raising hopes for blindness treatments and attracting media attention. News media provide an accessible health information source for patients and the public, but are often criticized for overemphasizing benefits and underplaying risks of novel...
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Na+/H+ exchange in the tumour microenvironment: Does NHE1 drive breast cancer carcinogenesis?
Download2015-01-01
Amith, Schammim Ray, Fong, Sunny, Baksh, Shairaz, Fliegel, Larry
Ionic messengers signal several critical events in carcinogenesis, including metastasis, the leading cause of patient mortality. The aberrant metabolic, proliferative and anti-apoptotic nature of neoplastic cells can be traced to the abnormal expression of their ion transporters and related...
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The na+/H+ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells
Download2015-01-01
Amith, Schammim Ray, Wilkinson, Jodi Marie, Baksh, Shairaz, Fliegel, Larry
Dysregulation of Na+/H+ exchanger isoform one (NHE1) activity is a hallmark of cells undergoing tumorigenesis and metastasis, the leading cause of patient mortality. The acidic tumor microenvironment is thought to facilitate the development of resistance to chemotherapy drugs and to promote...