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- 2Angiogenesis
- 2Angiostatin
- 2Protein-kinase-c
- 1A549 Human Lung Carcinoma Cell Line
- 1AMPA receptor
- 2Jurasz, P.
- 2Moncada de la Rosa, C.
- 2Radziwon-Balicka, A.
- 1Aroonassala Patten, Shunmoogum
- 1Bao, Hua
- 1Harding, John C. S.
- 4Graduate and Postdoctoral Studies (GPS), Faculty of
- 4Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 2Medicine and Dentistry, Faculty of
- 2Medicine and Dentistry, Faculty of/Cardiovascular Research Centre (CVRC)
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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Angiostatin inhibits endothelial MMP-2 and MMP-14 expression: A hypoxia specific mechanism of action
Download2013
Zielnik-Drabik, B., Jurasz, P., Radziwon-Balicka, A., Moncada de la Rosa, C., Ramer, C.
Angiostatin is an angiogenesis inhibitor in part generated by and released from platelets. Since platelets upon thrombus formation can give rise to areas of hypoxia, we investigated the effects of angiostatin on endothelial cell migration and apoptosis during hypoxia. Human microvascular...
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Differences in whole blood gene expression associated with infection time-course and extent of fetal mortality in a reproductive model of type 2 porcine reproductive and respiratory syndrome virus (PRRSV) infection
Download2016
Ladinig, Andrea, Stothard, Paul, Wilkinson, Jamie M., Kommadath, Arun, Plastow, Graham S., Harding, John C. S., Bao, Hua, Lunney, Joan K.
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant females causes fetal death and increased piglet mortality, but there is substantial variation in the extent of reproductive pathology between individual dams. This study used RNA-sequencing to characterize the whole...
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Genesis and Characterization of Human eNOS-Based Platelet Subpopulations. Implications for Haemostasis and Thrombosis
DownloadFall 2019
Background: Myocardial infarction (MI) and ischemic stroke are responsible for nearly half of all cardiovascular deaths in Canada. Platelets play a critical role in MI and ischemic stroke by forming thrombi that occlude coronary and cerebral arteries. In spite of abundant pharmacological agents...
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Manipulation of the Angiogenic Balance by Pharmacological Inhibition of Platelet PKC Signalling
DownloadFall 2012
Blood platelets mediate wound healing by preventing bleeding and by supporting growth of new blood vessels. Blood vessel growth is supported in part by growth factors released from platelet α-granules. Both platelet aggregation and α-granule release are mediated by intracellular signaling...
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Fall 2009
Aroonassala Patten, Shunmoogum
Glutamate AMPA receptors (AMPARs) are major excitatory receptors in the vertebrate CNS. In many biological systems there are changes in the properties of AMPARs during development that are essential for providing an increase in efficiency of information transfer between neurons and a refinement...
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2012
Radziwon-Balicka, A., Jurasz, P., Moncada de la Rosa, C.
Platelets, in addition to maintaining hemostasis, also stimulate angiogenesis by generating and releasing, upon activation, factors that promote the growth of new blood vessels. To date, at least 20 angiogenesis-regulating factors have been identified in platelets, including both promoters and...
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Fall 2016
Background: The cancer stem cell (CSC) theory suggests there are small populations of cancer cells that has stem cell-like characteristics, such as self-renewal. These CSCs are thought to be responsible for initiating new tumors following metastasis. Platelets have also been implicated in cancer...