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Skip to Search Results- 3Fliegel, Larry
- 1Abdulrahman, Nabeel
- 1Aguilar, Hector N
- 1Bairwa, Suresh C.
- 1Baral, Pravas Kumar
- 1Beaudoin, Marie-Soleil
- 12Graduate and Postdoctoral Studies (GPS), Faculty of
- 12Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 3Agricultural, Food and Nutritional Science, Department of
- 3Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 3Biochemistry, Department of
- 2Biochemistry, Department of/Journal Articles (Biochemistry)
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Fall 2015
Malignant glioma (MG), comprised of grade III (anaplastic astrocytoma) and grade IV (glioblastoma) astrocytoma, is the most common adult brain tumour, with an incidence of ~4 in 100 000 people. Despite aggressive treatment with surgery, radiation, and chemotherapy, survival remains dismal, with...
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Phosphorylation status of 72 kDa MMP-2 determines its structure and activity in response to peroxynitrite
Download2013-01-01
Jacob-Ferreira, Anna Laura, Kondo, Marcia Yuri, Baral, Pravas Kumar, James, Michael N., Holt, Andrew, Fan, Xiaohu, Schulz, Richard
Matrix metalloproteinase-2 (MMP-2) is a key intra- and extra-cellular protease which contributes to several oxidative stress related pathologies. A molecular understanding of 72 kDa MMP-2 activity, directly mediated by S-glutathiolation of its cysteine residues in the presence of peroxynitrite...
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Protein Kinase Mediated Regulation of the Na+/H+ Exchanger in the Rat Myocardium by MAP-Kinase-dependent Pathways
Download1999-01-01
Moor, Andrea Noor, Fliegel, Larry
We examined regulation of the Na+/H+ exchanger isoform 1 by phosphorylation in the rat myocardium. We utilized cell extracts from adult rat hearts, adult rat extracts fractionated by fast performance liquid chromatography, and extracts from cultured neonatal cardiac myocytes. The...
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Fall 2014
Regulation of microtubule dynamics is essential for many cellular processes, including proper assembly and function of the mitotic spindle. One mechanism for temporal and spatial regulation of microtubule dynamics is provided by the kinesin-13 microtubule depolymerizing enzymes, among which MCAK...
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Regulation of Cardiac Gap Junctional Communication: Metabolic regulation of Cx40 and Cx43 via phosphorylation
DownloadFall 2015
Alterations in myocardial metabolism and cardiac electrophysiology associated with structural heart disease generate lethal arrhythmias. Differential levels of energy (ATP) supply and demand are generated with structural heart disease that is expected to activate 5’-amp activated protein kinase...
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Rho-Kinase-Mediated Diphosphorylation of Myosin Regulatory Light Chain is a Unique Biochemical Mechanism in Human Uterine Myocytes
DownloadFall 2011
Rationale: Smooth muscle (SM) contraction results from activation of the cellular contractile machinery by phosphorylation of myosin regulatory light chain (RLC) at S19 (pRLC) by RLC kinase (MLCK). Subsequent phosphorylation at T18 yields diphosphorylated-RLC (ppRLC), which has been shown to...
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2005
van Houten, B., Patel, M., Chan, C. B., Orrenius, S. , Fariss, M. W.
Oxidative stress and mitochondrial oxidative damage have been implicated in the etiology of numerous common diseases. The critical mitochondrial events responsible for oxidative stress–mediated cell death (toxic oxidative stress), however, have yet to be defined. Several oxidative events...
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Fall 2018
Chloride intracellular channel (CLIC) proteins comprise six members CLIC1–CLIC6 in mammals and mediate functions not fully known. Their founding member was isolated from bovine kidney using the chloride channel inhibitor indanyloxyacetic acid-94, so CLICs were assumed to be typical anion...