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- 2Fatehi-Hassanabad, Zahra
- 1Anderson-Baron, Matthew N
- 1Berends, Harma
- 1Cant, John P.
- 1Chakrabarti, Subhadeep
- 10Graduate and Postdoctoral Studies (GPS), Faculty of
- 10Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 6Agricultural, Food and Nutritional Science, Department of
- 6Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 1Biological Sciences, Department of
- 1Biological Sciences, Department of/Journal Articles (Biological Sciences)
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A comprehensive assessment of peroxisome biology: ER-dependent peroxisome proliferation control, evolution of organelle inheritance in yeast and a Drosophila model system of Zellweger syndrome
DownloadFall 2013
The modern eukaryotic cell is a meshwork of encapsulating membranes that compartmentalize many distinct biochemical processes. It is complex. This complexity facilitates the many unique and diverse processes that aid the eukaryote in its growth, division and adaptation to its environment. A...
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A mechanistic model of intermittent gastric emptying and glucose-insulin dynamics following a meal containing milk components
Download2016
Cant, John P., Steele, Michael A., Stahel, Priska, MacPherson, Jayden A. R., Berends, Harma
To support decision-making around diet selection choices to manage glycemia following a meal, a novel mechanistic model of intermittent gastric emptying and plasma glucose-insulin dynamics was developed. Model development was guided by postprandial timecourses of plasma glucose, insulin and the...
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An ancestral role in de novo peroxisome assembly is retained by the divisional peroxin Pex11 in the yeast Yarrowia lipolytica
DownloadFall 2014
This thesis is on peroxisome evolution and reports my findings with regard to two major aspects of this process. First, I investigated the evolution of a peroxisomal protein family for which large expansions had been noted in diverse eukaryotes from a comparative genomic perspective and combined...
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Fall 2017
Flaviviruses are important human pathogens that have an enormous impact on global health. Examples that have been studied in my research include dengue virus (DENV), West Nile virus (WNV) and most recently, Zika virus (ZIKV). Currently, there are very few vaccines against or therapeutic...
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Expression of PPARα modifies fatty acid effects on insulin secretion in uncoupling protein-2 knockout mice
Download2007
Fatehi-Hassanabad, Zahra, Chan, Catherine B.
Aims/hypothesis In uncoupling protein-2 (UCP2) knockout (KO) mice, protection of beta cells from fatty acid exposure is dependent upon transcriptional events mediated by peroxisome proliferator-activated receptor-α (PPARα). Methods PPARα expression was reduced in isolated islets from UCP2KO and...
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2012
Wan, Zhongxiao, MacDonald, Tara, Wright, David C., Holloway, Graham P., Chan, Catherine B., Perry, Christopher G.
Background Adipose tissue mitochondria have been implicated as key mediators of systemic metabolism. We have shown that IL-6 activates AMPK, a mediator of mitochondrial biogenesis, in adipose tissue; however, IL-6−/− mice fed a high fat diet have been reported to develop insulin resistance. These...
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Fall 2010
Peroxisomes are indispensable organelles that perform many essential metabolic activities. Thus, eukaryotic cells have evolved molecular mechanisms to ensure the inheritance of peroxisomes from mother cell to daughter cell at cell division. In the budding yeast Saccharomyces cerevisiae, the class...