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Skip to Search Results- 1Abdualla, Radya Y
- 1Aghamohammadi Sereshki, Arash
- 1Alaazi, Dominic A
- 1Bhullar, Khushwant Singh
- 1Brotto,Andrew R
- 1Caballero, Hebert S
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Spring 2017
Von Willebrand Factor (VWF) is a multimeric adhesive glycoprotein that is exclusively expressed in endothelial cells (EC) and megakaryocytes. This procoagulant protein is involved in maintaining primary hemostasis and thrombus formation. However, there are pathological and physiological...
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Spring 2020
The population of older adults in Ghana is growing rapidly, and is projected to increase two-fold over the period 2015 to 2050. Despite the unprecedented growth, not much is known about the living conditions and wellbeing of older Ghanaians, in part due to a paucity of research in this area. This...
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An Exploration of the Association Between Lower Urinary Tract Symptoms and Falls in Older People
DownloadFall 2019
Falls and urinary incontinence are both highly prevalent in older people, and are both associated with significant impact on health, impairment of quality of life, increased healthcare resource use and costs. There is a well recognised but unexplained association between lower urinary tract...
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Anesthesia and the Aging Vasculature: Effects of Propofol on Hemodynamics and Vascular Function
DownloadSpring 2014
An increasing life expectancy in Canada has resulted in increasing proportions of elderly patients requiring anesthetic care for surgical procedures. Aging is associated with cardiovascular changes resulting in increased vasoconstriction and hypertension, and medications such as angiotensin...
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Are Sex and Estrogen Modulators of Sympathetic Vascular Control in Resting and Contracting Skeletal Muscle?
DownloadSpring 2018
The purpose of this thesis was to investigate whether sex and estrogen modulate sympathetic neurovascular control in resting and contracting skeletal muscle. This thesis also investigated the hypothesis that the effects of sex and estrogen on neurovascular control would be mediated by the signal...
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Can L-arginine Influence the Acute Hormonal, Metabolic, and Physiological Responses at Rest and Prior to Exercise?
DownloadFall 2012
L-arginine is a conditionally essential amino acid and has recently been purported as ergogenic for both strength and aerobic athletes; however, the value of oral L-arginine supplementation in physically active participants is controversial. The purpose of this dissertation was threefold: first...
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Cardioprotective effects of n-3 and n-6 PUFA derived epoxylipids against age-related cardiac alterations
DownloadSpring 2021
Age-associated changes leading to a decline in cardiac structure and function contribute to the increased susceptibility and incidence of cardiovascular diseases (CVD) in elderly individuals. A steady decline in mitochondrial function is recognized as an important biological consequence found in...
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Fall 2020
BACKGROUND: Parkinson’s disease (PD) is a progressive, neurodegenerative disorder characterized by resting tremors, instability, slowness of movement and rigidity, generally accompanied by non-motor symptoms such as mood disturbance, fatigue, constipation, incontinence and sleep disorders. Any...
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Fall 2021
Chronological aging is one of the greatest risk factors of tauopathies, yet our understanding about the underlying molecular mechanism is limited. Studying physiological aging often requires an extended timeline and thus presents a significant hurdle for modeling late-onset disorders. In this...