CLU, CR1 and PICALM: Genotypic Effects on Mild Cognitive Impairment Status and Stability

• Author / Creator

  Whitehead, Bonnie P

• Objective: Clinical utility of the Mild Cognitive Impairment (MCI) classification
  is diminished by uncertainty regarding procedures for detecting preceding
  transitions from normal aging (NA) and future transitions to Alzheimer’s disease 
  (AD). AD genetic markers may clarify underlying neurodegenerative etiology,
  thereby improving MCI classification. Method: Data are from the Victoria
  Longitudinal Study. We determine if AD-related genotypes [Apolipoprotein E
  (APOE; rs429358, rs7412), Clusterin (CLU; rs11136000), Complement Receptor
  1 (CR1; rs6656401), Phosphatidylinositol Binding Clathrin Assembly Protein
  (PICALM; rs541458)] independently or interactively distinguish (a) MCI (n=101)
  and NA adults (n=136) at baseline, and (b) longitudinal groups representing two-
  wave (M=4.5 years) profiles of MCI chronicity and change. Results: CLU and
  APOE independently predicted baseline MCI. Each gene independently
  differentiated one combination of longitudinal profiles. The CR1(2) x APOE(2) interaction differentiated numerous longitudinal profiles. Discussion: AD genetic markers are linked with transitions and chronicity involving NA and MCI, and
  may augment current MCI classification procedures.

• Subjects / Keywords

  • Mild Cognitive Impairment
  • CLU
  • PICALM
  • CR1
  • Aging

• Graduation date

  Fall 2013

• Type of Item

  Thesis

• Degree

  Master of Science

• DOI

  https://doi.org/10.7939/R3GX4532D

• License

  This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.