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CLU, CR1 and PICALM: Genotypic Effects on Mild Cognitive Impairment Status and Stability

  • Author / Creator
    Whitehead, Bonnie P
  • Objective: Clinical utility of the Mild Cognitive Impairment (MCI) classification is diminished by uncertainty regarding procedures for detecting preceding transitions from normal aging (NA) and future transitions to Alzheimer’s disease  (AD). AD genetic markers may clarify underlying neurodegenerative etiology, thereby improving MCI classification. Method: Data are from the Victoria Longitudinal Study. We determine if AD-related genotypes [Apolipoprotein E (APOE; rs429358, rs7412), Clusterin (CLU; rs11136000), Complement Receptor 1 (CR1; rs6656401), Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM; rs541458)] independently or interactively distinguish (a) MCI (n=101) and NA adults (n=136) at baseline, and (b) longitudinal groups representing two- wave (M=4.5 years) profiles of MCI chronicity and change. Results: CLU and APOE independently predicted baseline MCI. Each gene independently differentiated one combination of longitudinal profiles. The CR1(2) x APOE(2) interaction differentiated numerous longitudinal profiles. Discussion: AD genetic markers are linked with transitions and chronicity involving NA and MCI, and may augment current MCI classification procedures.

  • Subjects / Keywords
  • Graduation date
    2013-11
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R3GX4532D
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Department of Psychology
  • Supervisor / co-supervisor and their department(s)
    • Dr. Roger Dixon
  • Examining committee members and their departments
    • Lechelt, Katherine (Geriatric Medicine)
    • Camicioli, Richard (Neurology)
    • Wiebe, Sandra (Psychology)
    • Singhal, Anthony (Psychology)
    • Dixon, Roger (Psychology)