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Skip to Search Results- 2Veldhoen, Richard
- 1Abdualmjid,Reem J
- 1Abdurrahim, Amna E.
- 1Alsagheir, Ali I
- 1Araya, Luam Ellen
- 1Baghdasarian, Argishti
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Spring 2012
In Pulmonary Arterial Hypertension (PAH), pro-constrictive, pro-proliferative and anti-apoptotic diatheses converge to produce contraction and excessive proliferation of pulmonary artery smooth muscle cells (PASMC), a hallmark of PAH-vascular remodeling. The increased afterload causes right...
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An investigation of aminoglutethimide cytotoxicity and its role in activation of cell death signaling pathways
DownloadFall 2013
Aminoglutethimide (AG), a drug used for the treatment of breast and ovarian cancers, is known to cause toxicities such as agranulocytosis. To investigate its toxicity mechanisms, we have used quantitative proteomic analysis to gain insight into the proteome of Human Leukemia 60 (HL-60) treated...
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Anthocyanins and Gingerols Exhibit Synergism in their Anticancer and Antioxidant Effects in Vitro
DownloadFall 2022
Anthocyanins and gingerols are naturally occurring phenolic compounds abundant in berries and ginger, respectively. They have been reported to induce antioxidant effects, inhibit the growth of different cancer cell lines, and stimulate apoptosis by modulating different cellular signal pathways....
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Fall 2012
Taxane chemotherapy is widely used in the treatment of breast cancer. Despite its widespread clinical use, the molecular mechanisms of paclitaxel induced apoptosis remain unclear. Our laboratory has identified an important role for the BH3-only protein, BAD, in the paclitaxel induced cell death...
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Spring 2014
The introduction of WNV into North America in 1999 was followed by rapid spread throughout the continent. Today, WNV is an endemic pathogen in the west, with thousands of cases of severe infection reported annually. In addition to traditional vaccine research, there is an urgent need to...
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Characterization of the Humoral Immune Response Elicited Against a Prophylactic Vaccine Composed of Recombinant Envelope Glycoproteins from Hepatitis C Virus
DownloadFall 2018
A global prophylactic vaccine for Hepatitis C Virus (HCV) remains elusive. The diversity of the virus is a major hurdle; a successful vaccine will need to protect against all 7 HCV genotypes (gt). Our lab is developing a vaccine comprising the two envelope glycoproteins of HCV (E1E2). An...
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Characterization of the response of melanoma cell lines to inhibition of anti-apoptotic Bcl-2 proteins
DownloadSpring 2010
Malignant melanoma is resistant to almost all conventional forms of chemotherapy. Recent evidence suggests that anti-apoptotic proteins of the Bcl-2 family are overexpressed in melanoma and may contribute to melanoma’s striking resistance to apoptosis. ABT-737, a small-molecule inhibitor of...
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Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounter
DownloadSpring 2015
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
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Differentiation of human embryonic stem cells into hepatocytes and their in vivo application for hepatitis C viral production
DownloadFall 2014
Abstract Introduction: Chronic hepatitis C virus (HCV) infection is a global problem. The World Health Organization estimates that about 170 million individuals around the world are infected with HCV. Chronic HCV has a high rate of morbidity and mortality due to cirrhosis and hepatocellular...