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Skip to Search Results- 1Augustine, Aruna M
- 1Diakur, James Michael.
- 1Fliegel, Larry
- 1Gaetano, Cristoforo Giuseppe
- 1Karki, Pratap
- 1Keuling, Angela
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Fall 2011
In the Introduction of this thesis, consideration is given to historical and ongoing value of investing research efforts in the total synthesis of natural products. Following this discussion is an explanation of the factors that guided the selection of palmerolide A as a synthetic target. The...
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2011-01-01
Karki, Pratap, Li, Xiuju J., Schrama, David, Fliegel, Larry
The serine/threonine kinase B-Raf is the second most frequently occurring human oncogene after Ras. Mutations of B-Raf occur with the highest incidences in melanoma, and the most common mutant, V600E, renders B-Raf constitutively active. The sodium proton exchanger isoform 1 (NHE1) is a...
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Characterization of the response of melanoma cell lines to inhibition of anti-apoptotic Bcl-2 proteins
DownloadSpring 2010
Malignant melanoma is resistant to almost all conventional forms of chemotherapy. Recent evidence suggests that anti-apoptotic proteins of the Bcl-2 family are overexpressed in melanoma and may contribute to melanoma’s striking resistance to apoptosis. ABT-737, a small-molecule inhibitor of...
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Fall 2017
Mammalian Na+/H+ Exchanger 1 is a ubiquitously expressed membrane protein, which is dedicated to maintaining the acid-base balance in the cell. This balance is brought about by the exchange of one intracellular proton in exchange for extracellular sodium ion. NHE1 is the predominant isoform found...
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Fall 2012
Melanoma has the most rapidly rising incidence of all cancers and once metastasized it is very difficult to treat. This makes the identification of molecular pathways that are deregulated in melanoma a novel area of study. β-catenin (β-cat) is a multifunctional protein of the Wnt signaling...
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The curdlan and/or anti-VISTA monoclonal antibody enhances innate and adaptive immune responses in the mouse model of melanoma
DownloadSpring 2022
During the past decade, the field of immuno-oncology has been revolutionized by the emergence of immune checkpoint inhibitors (ICIs). However, acquired resistance to ICIs and relapse after immunotherapy are associated with defects in antigen presentation and the upregulation of exhaustion ligands...