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Skip to Search Results- 2Macauley, M. S.
- 2Macauley, Matthew S.
- 2Paulson, J. C.
- 1Bubb, Abigail K.
- 1Davies, Gideon J.
- 1Errington, Wesley J.
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2004
Okon, Mark, Schulman, Brenda A., Macauley, Matthew S., McIntosh, Lawrence P., Mackereth, Cameron D., Schärpf, Manuela, Errington, Wesley J.
Although sumoylation regulates a diverse and growing number of recognized biological processes, the molecular mechanisms by which the covalent attachment of the ubiquitin-like protein SUMO can alter the properties of a target protein remain to be established. To address this question, we have...
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Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance
Download2008
Bubb, Abigail K., Macauley, Matthew S., Davies, Gideon J., Vocadlo, David J. , Martinez-Fleites, Carlos
The O-GlcNAc post-translational modification is considered to act as a sensor of nutrient flux through the hexosamine biosynthetic pathway. A cornerstone of this hypothesis is that global elevation of protein O-GlcNAc levels, typically induced with the non-selective O-GlcNAcase inhibitor PUGNAc...
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Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22
2013
Pfrengle, F., Kawasaki, N., Paulson, J. C. , Macauley, M. S.
Differentiation of self from nonself is indispensable for maintaining B cell tolerance in peripheral tissues. CD22 and Siglec-G (sialic acid-binding Ig-like lectin G) are two inhibitory coreceptors of the BCR that are implicated in maintenance of tolerance to self Ags. Enforced ligation of CD22...
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Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells
2014
Paulson, J. C. , Macauley, M. S.
Infusion of blood cells from a donor can induce humoral tolerance in a recipient and increase the probability of successful organ transplant, a clinical method defined as donor-specific transfusion (DST). Despite the clinical success of DST, the immunological mechanisms by which blood cells...
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2015
Klassen, John S., Yao, Yuyu, Serpe, Michael J., Xu, Wenwen
Anisotropic particles have generated an enormous amount of research interest due to their applications for drug delivery, electronic displays and as micromotors. However, up till now, there is no single protocol capable of generating particles of “patchy” composition with a variety of...