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Skip to Search Results- 3Matrix Metalloproteinase-2
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Novel Roles of Matrix Metalloproteinase-2 in Mitochondrial and Endoplasmic/Sarcoplasmic Reticulum Dysregulation
DownloadFall 2024
Matrix metalloproteinase-2 (MMP-2) is a ubiquitous multifunctional protease that cleaves both extracellular and intracellular proteins. MMP-2 is synthesized as an inactive zymogen. It is rapidly activated inside the cell in response to oxidative stress during different cardiac pathologies such as...
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Fall 2016
Background: The cancer stem cell (CSC) theory suggests there are small populations of cancer cells that has stem cell-like characteristics, such as self-renewal. These CSCs are thought to be responsible for initiating new tumors following metastasis. Platelets have also been implicated in cancer...
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The Role of Matrix Metalloproteinase-2 in the Pathophysiology of a Reduced Utero-Placental Perfusion Pressure Model of Preeclampsia
DownloadFall 2012
Preeclampsia is a leading cause of maternal and fetal morbidity/mortality and induced preterm birth. Endothelin-1 (ET-1) is a potent vasoactive agent, shown to be involved in the vascular endothelial dysfunction of preeclampsia. Big endothelin (bigET) is cleaved to ET-1 by several enzymes...