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Skip to Search Results- 3Intracellular ice formation
- 2Computer modeling
- 2Cryobiology
- 2TF-1
- 1Cryobiological modelling
- 1Cryopreservation
- 1Elliott, J. A.
- 1Elliott, J.A.
- 1McGann, L. E.
- 1McGann, L.E.
- 1Prickett, Richelle Catherine
- 1Ross-Rodriguez, L. U.
- 2Chemical and Materials Engineering, Department of
- 2Chemical and Materials Engineering, Department of/Research Articles and Materials (Chemical and Materials Engineering)
- 1Graduate and Postdoctoral Studies (GPS), Faculty of
- 1Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
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Investigating cryoinjury using simulations and experiments: 1. TF-1 cells during two-step freezing (rapid cooling interrupted with a hold time)
Download2014-09-22
McGann, L. E., Ross-Rodriguez, L. U., Elliott, J. A.
There is significant interest in designing a cryopreservation protocol for hematopoietic stem cells (HSC) which does not rely on dimethyl sulfoxide (Me2SO) as a cryoprotectant. Computer simulations that describe cellular osmotic responses during cooling and warming can be used to optimize the...
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Investigating cryoinjury using simulations and experiments: 2. TF-1 cells during graded freezing (interrupted slow cooling without hold time)
Download2014-09-22
McGann, L.E., Ross-Rodriguez, L.U., Elliott, J.A.
Cryopreservation plays a key role in the long-term storage of native and engineered cells and tissues for research and clinical applications. The survival of cells and tissues after freezing and thawing depends on the ability of the cells to withstand a variety of stresses imposed by the...
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Spring 2010
Mathematical modelling of cellular osmotic responses to low temperatures is being increasingly used to overcome obstacles in the successful cryopreservation of cells and tissues. Current cryobiological models often contain simplifying assumptions regarding the solution behaviour of the...