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A Systematic Review of Instruments to Assess Organizational Readiness for Knowledge Translation in Health Care
Download2014
Attieh, Randa, Ouimet, Mathieu, Estabrooks, Carole A., Légaré, France, Gagnon, Marie-Pierre, Grimshaw, Jeremy, Ghandour, El Kebir
Background: The translation of research into practices has been incomplete. Organizational readiness for change (ORC) is a potential facilitator of effective knowledge translation (KT). However we know little about the best way to assess ORC. Therefore, we sought to systematically review ORC...
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Applying the risk of bias tool in a systematic review of combination long-acting beta-agonists and inhaled corticosteroids for persistent asthma.
Download2011
Seida, J., Vandermeer, B., Hartling, L., Dryden, D. M., Rowe, B. H., Bond, K.
Background The Risk of Bias (RoB) tool is used to assess internal validity of randomized controlled trials (RCTs). Our objectives were to: 1) evaluate inter-rater agreement of the RoB tool; 2) determine the time to access supplemental study information; 3) compare the RoB tool with the Jadad...
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Biochemical analysis of respiratory metabolism in the heterofermentative Lactobacillus spicheri and Lactobacillus reuteri
Download2015-01-01
Ianniello, Rocco G., Zheng, Jinshui, Zotta, Teresa, Ricciardi, Annamaria, Gänzle, Michael G.
Aims: This study evaluated the aerobic and respiratory metabolism in Lactobacillus reuteri and Lactobacillus spicheri, two heterofermentative species used in sourdough fermentation. Methods and Results: In silico genome analysis, production of metabolites and gene expression of pyruvate oxidase,...
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2016-01-01
The primary principle underlying the application of genomics is that it has the most value for difficultand expensive to measure traits. These traits will differ between species and probably also between markets. Maintenance of health will be one of the biggest challenges for efficient livestock...
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Reflections on the Cost of "Low-Cost" Whole Genome Sequencing: Framing the Health Policy Debate
Download2014-10-24
Miller, Fiona A., Hogarth, Stuart, Evans, Jim, McCabe, Christopher, Pullman, Daryl, Joly, Yann, Szego, Michael J., Bubela, Tania, Fishman, Jennifer, Sankar, Pamela, Cook-Deegan, Robert, Biesecker, Barbara, Ravitsky, Vardit, Borry, Pascal, K. Cho, Mildred, Ungar, Wendy, J., Ossorio, Pilar, Kato, Kazuto, Wilson, Brenda, McGuire, Amy, Soo-Jin Lee, Sandra, Caulfield, Timothy, Rothenberg, Karen, Rousseau, Francois, Etchegary, Holly, Carroll, June C.
The cost of whole genome sequencing is dropping rapidly. There has been a great deal of enthusiasm about the potential for this technological advance to transform clinical care. Given the interest and significant investment in genomics, this seems an ideal time to consider what the evidence tells...
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2008-01-01
Caulfield, Timothy, McGuire, Amy L., Cho, Mildred, Buchanan, Janet A., Burgess, Michael M., Danilczyk, Ursula, Diaz, Christina M., Fryer-Edwards, Kelly, Green, Shane K., Hodosh, Marc A., Juengst, Eric T., Kaye, Jane, Kedes, Laurence, Knoppers, Bartha M., Lemmens, Trudo, Meslin, Eric M., Murphy, Juli, Nussbaum, Robert L., Otlowski, Margaret, Pullman, Daryl, Ray, Peter N., Sugarman, Jeremy, Timmons, Michael
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2014
Plastow, G., Stothard, P., Moore, S., Bao, H., Meng, Y., Liao, X.
Gene duplication is a widespread phenomenon in genome evolution, and it has been proposed to serve as an engine of evolutionary innovation. In the present study, we performed the first comprehensive analysis of duplicate genes in the bovine genome. A total of 3131 putative duplicated gene pairs...