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Skip to Search Results- 1Bhardwaj, Paramjit P
- 1Blázquez, M.
- 1Bosma, P.T.
- 1Chang, J.P.
- 1Dobberthien, Brennen Jay
- 1Docherty, K.
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Fall 2022
Ia afferents conveying proprioceptive information to the spinal cord, and the regulation of action potential conduction along these afferents, are vital for motor function. After injury to the central nervous system (CNS), hyperexcitability in proprioceptive and other afferent pathways to the...
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GABAA Receptors and Tonic Inhibition: Towards an Improved Understanding of Agonist Binding and in vivo Expression of the Extrasynaptic a4b3d Subtype
DownloadFall 2013
The GABAA receptor is the major inhibitory neurotransmitter receptor in the central nervous system. Receptors containing the delta subunit generate tonic inhibition due to their extrasynaptic expression, high affinity for gamma-aminobutyric acid (GABA), and slow densensitization kinetics. The...
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Investigating the Effects of N2-Acetylphenelzine in the Sexes in Experimental Autoimmune Encephalomyelitis
DownloadFall 2017
Chronic pain is a highly prevalent symptom in Multiple Sclerosis (MS) and affects approximately half of patients at some stage of the disease. MS affects women more frequently than men and neuropathic pain is also reported as more severe, and frequent, in females with the disease. The underlying...
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Fall 2020
In the perimenopausal period, an event marked by end of menstrual cycle regularity, women are at a greater risk of either experiencing a reoccurrence of a major depressive episode (MDE), or presenting with their first MDE. This risk is greater in women with a history of mood vulnerability related...
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Fall 2015
Calcium/calmodulin dependent protein kinase 2 (CaMKII) is a multifunctional serine/threonine kinase that is highly abundant in the central nervous system. It plays important roles in many neuronal functions, including neurite extension and maturation, activity-dependent synaptic plasticity and...
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Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 protein
DownloadSpring 2013
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...
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Spectral Editing for Detection of Oncologically Relevant Metabolites with In-Vivo Magnetic Resonance Spectroscopy at 9.4 T
DownloadFall 2019
Short echo time (TE) magnetic resonance spectroscopy (MRS) techniques with spectral fitting are commonly employed approaches for brain metabolite quantification at 9.4 T. However, there is a significant overlap of peaks in short-TE spectra, even at 9.4 T. To better resolve resonances, spectral...
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The pulmonary vasculature during exercise in health and mild chronic obstructive pulmonary disease
DownloadFall 2017
The purpose of this dissertation was to characterize the response of the pulmonary vasculature to exercise in health (including a pharmacological intervention) and in individuals with mild chronic obstructive lung disease. The first project studied the effect of a dopamine receptor blockade on...
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Variation in in vivo prefrontal GABA, glutamate and glutamine – effects of reproductive factors, cortisol and major depressive disorder
DownloadFall 2017
Variations in glutamate and γ-aminobutyric acid (GABA), excitatory and inhibitory amino acid neurotransmitters in the brain, have been linked with cyclical changes across the menstrual cycle and in stress and stress-related mental disorders. We used 3.0 Tesla proton magnetic resonance...
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γ-Aminobutyric Acid Up-Regulates the Expression of a Novel Secretogranin-II Messenger Ribonucleic Acid in the Goldfish Pituitary
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Docherty, K., Chang, J.P., Blázquez, M., Trudeau, V.L., Bosma, P.T.
An RNA-arbitrarily primed PCR differential display strategy was used to identify candidate genes in the pituitary that are up-regulated by endogenously activated g-aminobutyric acid (GABA) systems that may also be involved in the control of reproduction. Goldfish were injected with the GABA...