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Notch regulates the growth-promoting nitric oxide cGMP-dependent pathway in epithelial ovarian cancer and ovarian surface epithelium cells
DownloadSpring 2014
El-Sehemy, Ahmed Ali Ahmed Ali
Ovarian cancer is the leading cause of mortality among gynecologic cancers. There are several subtypes of ovarian cancer, amongst which epithelial ovarian cancer (EOC) makes up to 90% of all ovarian cancers. The current treatment for EOC consists of debulking surgery followed by a...
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Novel mechanisms of carboplatin resistance in epithelial ovarian cancer and their therapeutic potential
DownloadFall 2015
Ovarian cancer is the fifth leading cause of cancer-related mortality in women. Epithelial ovarian cancer (EOC) constitutes approximately 90% of all ovarian malignancies. Platinum-based compounds have been used to treat EOC, with carboplatin currently being used as a first-line therapeutic agent...