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Skip to Search Results- 1Anderson, G. I.
- 1Burns, B. M.
- 1Coatham, Mackenzie L.
- 1Eindorf, T.
- 1Fitzsimmons, C.
- 1Ghanipoor-Samami, M.
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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
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Assessing the Potential for Hybrid Vigour Within a Species: Disparate Population Breeding of Balsam Poplar
DownloadFall 2021
When two or more species are crossed to produce hybrid progeny, some of them can be expected to yield a growth performance far superior to that of either parent (i.e., hybrid vigour/heterosis). To date, there have been few attempts to examine whether hybrid vigour can be achieved by crossing...
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Spring 2022
Some of the most aggressive endometrial cancer cases display extensive heterogeneity within the same tumor in the form of mixed undifferentiated and well-differentiated phenotypes. The emergence of dedifferentiation in higher grade endometrial carcinomas presents an obstacle for both timely and...
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DNA methylation patterns derived from fetal vulnerability to maternal smoking relate to future child outcomes
DownloadSpring 2021
Fetuses exposed to maternal smoking during pregnancy (MSP) are at higher risk of developing illnesses such as obesity, diabetes and heart, lung and mental health disease. These disorders are part of a group of non-fatal, non-communicable common complex diseases (CCDs) that form the greatest...
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Homology modeling of Suv39h1 and discovery of its small molecule inhibitors by virtual screening and their in vitro validation
DownloadFall 2013
Epigenetic modifications are carried out by specific enzymes and are reversible making them a viable and attractive target to design inhibitors to reset the epigenetic regulatory machinery of the cell and restore it to its normal state. Suppressor of variegation 3-9 homolog 1 (Suv39h1) is a...
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Maternal and Paternal Genomes Differentially Affect Myofibre Characteristics and Muscle Weights of Bovine Fetuses at Midgestation
Download2013
Kruk, Z. A., Xiang R., Rutley, D. L., Thomsen, D. A., Anderson, G. I., Fitzsimmons, C., Ghanipoor-Samami, M., Hiendleder, S., Roberts, C. T., Eindorf, T., Burns, B. M., Greenwood, P. L., Johns, W. H.
Postnatal myofibre characteristics and muscle mass are largely determined during fetal development and may be significantly affected by epigenetic parent-of-origin effects. However, data on such effects in prenatal muscle development that could help understand unexplained variation in postnatal...
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Spring 2023
Nutrition of the beef cow during pregnancy influences fetal development and potential changes in phenotype. On average 9-10% of beef cows are below the optimal condition score of 2.5/5 at both pre-breeding and pregnancy tests, indicating potential nutritional stress during gestation (Waldner and...
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Oral Porphyromonas gingivalis Infection Induces Epigenetic Changes that Promote Persistence of Cardiovascular Disease Risk
DownloadFall 2020
In the last two decades, periodontitis has become recognized as a risk factor for cardiovascular disease (CVD), a term that encompasses many circulatory disorders, often underpinned by atherosclerosis. One of the major questions regarding this association has been whether elimination of...
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Spring 2018
Head and neck squamous cell carcinoma (HNSCC) is the 6th most prevalent cancer worldwide with rates of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) dramatically increasing. The overexpression of enhancer of zeste homolog 2 (EZH2), a histone methyltransferase...
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Fall 2018
Early mammalian development cannot progress without targeted temporal and spatial expression of genes. Changing the accessibility of DNA to transcriptional machinery is one critical way gene expression is controlled. This process, known as chromatin remodeling, is vital for formation of the...