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Skip to Search Results- 2Al Sayah, Fatima
- 1Abdussalam, Ali MA
- 1Abu Alrub, Osama Y
- 1Aburasayn, Hanin
- 1Achtymichuk, Karly A
- 1Adame Perez, Stephany
- 16Department of Agricultural, Food, and Nutritional Science
- 8Department of Surgery
- 8Faculty of Pharmacy and Pharmaceutical Sciences
- 8School of Public Health
- 5Medical Sciences-Paediatrics
- 4Department of Public Health Sciences
- 2Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 2Eurich, Dean (School of Public Health)
- 2Johnson, Jeff A. (School of Public Health Sciences, University of Alberta)
- 2Proctor, Spencer (AFNS)
- 2Williams, Beverly (Faculty of Nursing, University of Alberta)
- 1Adamowicz, Vic (Rural Economy)
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Characterization of Human Pancreatic Beta-cell Progenitors as a Means to Alleviate the Shortage of Donor Tissue for Islet Transplantation
DownloadFall 2012
The current shortage of islet tissue from cadaveric human donors is not sustainable and will preclude islet transplantation from becoming a widespread therapeutic treatment for those with type 1 diabetes. A potential alternative source of tissue may be through isolating, expanding, and...
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Characterizing the Mesolimbic Dopamine Reward Pathway in a Magel2-null Mouse, a Model of Prader-Willi Syndrome
DownloadFall 2016
Prader-Willi Syndrome (PWS) is a genetic disorder characterized by extreme hyperphagia that can lead to severe obesity. The abnormal motivation to eat in PWS suggests a disruption in the hedonic feeding pathway, which is feeding based on reward as opposed to physiological need. Hedonic feeding is...
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Clinical and Translational Studies Advancing Clinical Implementation of Stem Cell-Derived Islet Transplantation
DownloadSpring 2024
Twenty-years ago Shapiro et al. revolutionized islet transplantation (ITx), realizing the potential for a cell-based diabetes treatment. Despite improvements, ITx remains restricted by organ donor limitations and immunosuppression. Stem cell (SC)-derived ITx (SC Tx) could eliminate these...
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Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounter
DownloadSpring 2015
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
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Fall 2012
Establishing mixed hematopoietic chimerism is a promising approach to develop donor-specific tolerance to transplanted organs. Establishing tolerance may eliminate the need for long-term immunosuppressive therapy, prevent chronic rejection and in the case of Type 1 Diabetes (T1DM), reverse...
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Fall 2011
The prevalence of childhood obesity has increased dramatically over the last three decades in Canada with substantial consequences for the physical, mental, and economic wellbeing of the population. The overarching objective of this thesis was to examine the various aspects of childhood obesity...
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Development of Conversation Cards for Adolescents©: A patient-centered communication and behavior change tool for adolescents with obesity and health care providers
DownloadFall 2019
Background. Given adolescents’ increasing desire for independence and autonomy, there is a need for research to examine their lived experiences, including concerns, preferences, and priorities. In the context of lifestyle modification for weight management, most adolescents with obesity exhibit...
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Fall 2014
An individual’s body weight is tightly regulated by balancing food intake with energy expenditure. This is accomplished in part by secretion of the hormone leptin by adipocytes, an excess of which signals to reduce appetite and increase activity through action in the hypothalamic region of the...
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Diabetes and Influenza-Attributable Illness: The Rationale for Targeted Influenza Vaccinations in Adults with Diabetes
DownloadFall 2012
While guidelines for seasonal influenza vaccinations single out working age (< 65) adults with diabetes, vaccination rates in this group remain below national targets. Historically, there has been limited evidence to support these guidelines. This dissertation comprises four studies investigating...
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Drug Exposure Definition and Healthy User Bias Impacts on the Evaluation of Oral Anti Hyperglycemic Therapies
DownloadFall 2017
Accurate estimation of medication use is an essential component of any pharmacoepidemiological research as exposure misclassification will threaten study validity and lead to spurious associations. Many pharmacoepidemiological studies use simple definitions, such as the categorical “any versus no...