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Fall 2014
Fungal pathogens are recognized by Dectin-1, a pattern recognition receptor expressed on mammalian innate immune cells. Dectin-1 detects β-glucans, which are polymers of glucose that are a main component of the fungal cell wall. While purified, soluble β-glucans have been used in the clinic as...
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Molecular Mechanisms of the Activation of the Pattern Recognition Receptor Dectin-1 and its Induction of Immune Responses
DownloadFall 2014
In the past two decades, a rising number of fungi have emerged as serious human pathogens and the incidence of invasive fungal infections has increased enormously. Millions of people contract fungal diseases that kill at least as many people as tuberculosis or malaria, yet the global burden of...
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The curdlan and/or anti-VISTA monoclonal antibody enhances innate and adaptive immune responses in the mouse model of melanoma
DownloadSpring 2022
During the past decade, the field of immuno-oncology has been revolutionized by the emergence of immune checkpoint inhibitors (ICIs). However, acquired resistance to ICIs and relapse after immunotherapy are associated with defects in antigen presentation and the upregulation of exhaustion ligands...