This decommissioned ERA site remains active temporarily to support our final migration steps to https://ualberta.scholaris.ca, ERA's new home. All new collections and items, including Spring 2025 theses, are at that site. For assistance, please contact erahelp@ualberta.ca.
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Fall 2022
Background: Hypertrophic scars (HTS) are a dermal fibroproliferative disorder that commonly occurs following burn injury. Due to the intricate nature of the wound healing process and an incomplete understanding of the molecular mechanisms involved in HTS formation, current treatments have...
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Effect of Adenovirus-mediated Decorin Gene Therapy on Fibrotic Remodeling in Tissue-engineered Skin
DownloadFall 2016
Background: Hypertrophic scar (HTS) is a fibroproliferative disorder of the skin that results in the development of painful, red, raised scar lesions. Transforming growth factor beta 1 (TGF-β1) has been implicated as a key driver of this disorder. Primarily, these effects include an increased...
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Novel Mediators and Medical Prevention of Bladder Fibrosis After Partial Bladder Outlet Obstruction
DownloadFall 2012
Introduction: Partial bladder outlet obstruction (pBOO) is a significant problem that can affect renal health. We hypothesize that changes occur in small leucine-rich proteoglycan (SLRP) composition of extracellular matrix over time in this process. We hypothesize that medical treatment of...
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The Role of Decorin and Factors Influencing its Expression in Wound Healing and Hypertrophic Scarring
DownloadSpring 2016
Hypertrophic scarring following deep burn injury is a significant problem for many burn patients, and can cause lifelong morbidity including impaired physical function, and reduced psychosocial function from poor cosmesis. While a significant body of research exists, there is still no gold...