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Skip to Search Results- 13Wishart, D.S.
- 9Stothard, Paul
- 8University of Alberta, Department of Biological Sciences
- 6Wang, J.
- 5Cruz, J.A.
- 5Li, John
- 44Graduate and Postdoctoral Studies (GPS), Faculty of
- 44Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 40Biological Sciences, Department of
- 32Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 12Agricultural, Food and Nutritional Science, Department of
- 12Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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Fall 2017
Merlin and the ezrin-radixin-moesin (ERM) proteins are key organizers of the cell cortex through linking membrane-associated proteins to the underlying actin cytoskeleton. Merlin and the ERM proteins have been implicated in the maintenance of cell integrity, adhesion, and motility during tissue...
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Characterization of the crosstalk between immunity and metabolism in Drosophila melanogaster model
DownloadFall 2021
Immune and metabolic pathways collectively contribute to the containment of microbial invaders, and persistent activation of immune responses contribute to the development of severe metabolic disorders. To determine how interaction between innate immune system and metabolic responses affected...
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Classifying Crystal Structures of Binary Compounds AB through Cluster Resolution Feature Selection and Support Vector Machine Analysis
Download2016
Adutwum, Lawrence A. , Harynuk, James, Mar, Arthur, Oliynyk, Anton O.
Partial least-squares discriminant analysis (PLS-DA) and support vector machine (SVM) techniques were applied to develop a crystal structure predictor for binary AB compounds. Models were trained and validated on the basis of the classification of 706 AB compounds adopting the seven most common...
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Fall 2015
There is a concern that brain tumours are underreported in the Alberta Cancer Registry (ACR), yet no studies have been performed to investigate this issue. This study addresses the concern of underreporting of brain tumours in the ACR by assessing case ascertainment of primary brain tumours cases...
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2012
Stothard, Paul, Arantes, Adriano S., Grant, Jason R.
Background Continued sequencing efforts coupled with advances in sequencing technology will lead to the completion of a vast number of small genomes. Whole-genome comparisons represent an important part of the analysis of any new genome sequence, as they can provide a better understanding of the...
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Spring 2012
Accurately identifying strand residues (beta-residues) from protein sequences aids prediction and analysis of numerous structural and functional aspects of proteins. This thesis is focused on improving sequence-based prediction of strand residues and strands, which in turn would lead to better...
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Computational support systems for prediction and characterization of protein crystallization outcomes
DownloadFall 2013
Analysis of protein structures may reveal their function, regulation and interactions. Almost 90% of the known protein structures were solved using X-ray crystallography; however, many more structures remain unsolved. Protein Structure Initiative (PSI) project was created to speed up structure...
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CS23D: A web server for rapid protein structure generation using NMR chemical shifts and sequence data
Download2008
Wishart, D.S., Berjanskii, M., Arndt, D., Lin, G., Tang, P., Zhou, J.
CS23D (chemical shift to 3D structure) is a web server for rapidly generating accurate 3D protein structures using only assigned nuclear magnetic resonance (NMR) chemical shifts and sequence data as input. Unlike conventional NMR methods, CS23D requires no NOE and/or J-coupling data to perform...
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CycA is involved in the control of endoreplication dynamics in the Drosophila bristle lineage
Download2012
Campbell, S.D., Sallé, J., Gho, M., Audibert, A.
Endocycles, which are characterised by repeated rounds of DNA replication without intervening mitosis, are involved in developmental processes associated with an increase in metabolic cell activity and are part of terminal differentiation. Endocycles are currently viewed as a restriction of the...