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Skip to Search Results- 1Harbison, Adrian Mark.
- 1Lin, Zhen
- 1Mireau, Laura R.
- 1Nakhaei-Nejad, Maryam
- 1Raha, Srijan
- 1Romao, Josue M
- 2Department of Oncology
- 2Medical Sciences-Shantou in Laboratory Medicine and Pathology
- 1Department of Agricultural, Food, and Nutritional Science
- 1Department of Anatomy and Cell Biology
- 1Department of Medical Microbiology and Immunology
- 1Department of Medical Sciences
- 1Guan, Leluo (Department of Agricultural, Food, and Nutritional Science, University of Alberta)
- 1Lewis, John D. (Oncology)
- 1Li-Yan Xu (Institute of Oncological Pathology, Shantou University Medical College)
- 1Mason, Andrew (Department of Medicine)
- 1Murray, Allan G (Medicine)
- 1Raymond Lai (Dept. of Lab Med & Pathology, University of Alberta)
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Application of Next Generation Sequencing and Bioinformatic Approaches to the Study of Influenza Virus Strains and MiRNA Profiling in Liver Diseases
DownloadSpring 2016
Analysis and interpretation of next generation sequencing data has posed a significant challenge to researchers, especially to those who are not equipped with expertise in bioinformatics. In this thesis, I investigated three different biomedical questions using NGS and bioinformatic approaches,...
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Deciphering the molecular mechanisms underlying the pathobiology of esophageal squamous cell carcinoma
DownloadFall 2015
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers worldwide, largely due to a high frequency of tumor invasion/metastasis, chemoresistance and recurrence. In this study, we explored from different perspectives the molecular mechanisms behind these aggressive features of...
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Spring 2014
Adipose tissue plays an important role in the energetic balance, but it is also an important aspect of meat quality and animal productivity. However, the understanding on how fat metabolism is regulated in beef cattle is not clear. This research aimed at exploring how bovine adipose tissue is...
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The biological function and clinical significance of STAT1 in esophageal squamous cell carcinoma
DownloadFall 2016
Although esophageal cancer makes up only 1% of all the cancers in western countries, it is a common death cancer in other areas, especially China. Esophageal squamous cell carcinoma (ESCC) is the most common type of esophageal cancer in Chaoshan, an area with high incidence rate of this disease...
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The role of endothelial PI3 kinase activity and IQGAP1 in regulation of lymphocyte diapedesis
DownloadFall 2011
Leukocyte extravasation is a fundamental process of the inflammatory responses. The mechanisms that control remodelling of endothelial (EC) shape and adhesive contacts during leukocyte transendothelial migration (TEM) are not completely understood. We studied the role of EC phosphatidylinositol...
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Fall 2017
Metastasis is the leading cause of cancer-related deaths, yet there are no therapies that directly target this process. To identify potential therapeutic targets of metastatic dissemination, we recently completed the first whole human genome shRNA screen using a novel avian embryo intravital...