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Skip to Search Results- 1Baluch, Aliyah
- 1Beilman, Candace L
- 1Bergeron, Amber
- 1Chappell, Kaitlyn
- 1Dai, Jiayi
- 1El-Matary, Wael
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A large deletion virus reveals the presence of previously uncharacterized vaccinia virus inhibitors of NF-kB signaling
DownloadFall 2010
The classical Nuclear Factor kappa B (NF-κB) signaling pathway is an important regulator of inflammation and innate immune responses. Poxviruses, including vaccinia virus, encode multiple immune evasion proteins, including a growing number of NF-κB inhibitors. To determine if additional vaccinia...
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An Individualized and Multi-faceted Transition Intervention is Needed for Pediatric Patients with Inflammatory Bowel Disease
DownloadFall 2016
The transition of chronically ill patients from pediatric to adult care can be challenging for patients and families and there is no gold standard for how to facilitate this process. An unsuccessful transition has been associated with more negative health outcomes. It is generally agreed upon by...
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Fall 2010
Mast cells are immune cells important in innate immunity. Besides their role in asthma and allergies, mast cells are critical effector cells against various pathogens. Mast cells are established to be protective against bacterial infections, but little is known about their functions in viral...
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Application of Next Generation Sequencing and Bioinformatic Approaches to the Study of Influenza Virus Strains and MiRNA Profiling in Liver Diseases
DownloadSpring 2016
Analysis and interpretation of next generation sequencing data has posed a significant challenge to researchers, especially to those who are not equipped with expertise in bioinformatics. In this thesis, I investigated three different biomedical questions using NGS and bioinformatic approaches,...
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Spring 2012
The aim of this work was to examine any possible IBD activity-related variations in immunoglobulin A (IgA) anti-tissue transglutaminase (tTG) levels in children with IBD. The prevalence of CD in children with IBD was also examined. In a prospective cohort study, children with IBD were screened...
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Spring 2014
The introduction of WNV into North America in 1999 was followed by rapid spread throughout the continent. Today, WNV is an endemic pathogen in the west, with thousands of cases of severe infection reported annually. In addition to traditional vaccine research, there is an urgent need to...
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Characterizing the effects of differentially adapted influenza PB2 proteins on duck MAVS-mediated interferon beta signaling
DownloadFall 2015
The influenza A viral RNA polymerase is responsible for viral replication and greatly affects influenza A virus (IAV) virulence and host range. The PB2 influenza polymerase subunit is the primary polymerase determinant of influenza host range and virulence. It was previously shown that PB2...
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Fall 2016
Anti-TNF therapy is effective for the induction and maintenance of remission in patients with inflammatory bowel disease (IBD). The benefits of anti-TNF therapy include improved quality of life, steroid discontinuation, and reduced hospitalization and surgery rates. Due to their high costs and...
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Development of Oral Influenza Vaccine Delivery System Utilizing pH Responsive Pored Microparticles
DownloadFall 2015
Influenza is a major respiratory disease caused by influenza virus. Recent spread of the extremely pathogenic avian and swine influenza viruses paint a morbid picture of the emergence of a more lethal influenza virus in future. Currently, hypodermic needles are being dominantly employed in...