Celiac disease in children with inflammatory bowel disease: a prospective cohort study

  • Author / Creator
    El-Matary, Wael
  • The aim of this work was to examine any possible IBD activity-related variations in immunoglobulin A (IgA) anti-tissue transglutaminase (tTG) levels in children with IBD. The prevalence of CD in children with IBD was also examined. In a prospective cohort study, children with IBD were screened for celiac disease using anti-tTG IgA antibodies and endoscopy performed if positive. Age-matched controls without IBD were recruited. One hundred and sixty four children were recruited in each arm of the study. There was no correlation between changes in IgA anti-tTG antibody titers and changes in disease activity indices. The prevalence of celiac disease among patients and controls was similar (1/164 (0.6%)). In children with IBD, changes in disease activity do not significantly affect serum levels of anti-tTG IgA antibodies. Anti-tTG IgA antibodies should not be used to monitor IBD activity. Children with IBD should not be routinely screened for CD.

  • Subjects / Keywords
  • Graduation date
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
  • Institution
    University of Alberta
  • Degree level
  • Department
    • School Public Health Sciences
  • Specialization
    • Clinical Epidemiology
  • Supervisor / co-supervisor and their department(s)
    • Spady, Donald (Department of Pediatrics, Faculty of Medicine)
  • Examining committee members and their departments
    • Dieleman, Levinus (Department of Gastroenterology, Faculty of Medicine)
    • Fedorak, Richard (Department of Gastroenterology, Faculty of Medicine)
    • Senthilselvan, Ambikaipakan (School of Public Health)