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- 7Crohn's disease
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- 3Vaccinations
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Fall 2010
Mast cells are immune cells important in innate immunity. Besides their role in asthma and allergies, mast cells are critical effector cells against various pathogens. Mast cells are established to be protective against bacterial infections, but little is known about their functions in viral...
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Application of Next Generation Sequencing and Bioinformatic Approaches to the Study of Influenza Virus Strains and MiRNA Profiling in Liver Diseases
DownloadSpring 2016
Analysis and interpretation of next generation sequencing data has posed a significant challenge to researchers, especially to those who are not equipped with expertise in bioinformatics. In this thesis, I investigated three different biomedical questions using NGS and bioinformatic approaches,...
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Characterizing the effects of differentially adapted influenza PB2 proteins on duck MAVS-mediated interferon beta signaling
DownloadFall 2015
The influenza A viral RNA polymerase is responsible for viral replication and greatly affects influenza A virus (IAV) virulence and host range. The PB2 influenza polymerase subunit is the primary polymerase determinant of influenza host range and virulence. It was previously shown that PB2...
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Development of Oral Influenza Vaccine Delivery System Utilizing pH Responsive Pored Microparticles
DownloadFall 2015
Influenza is a major respiratory disease caused by influenza virus. Recent spread of the extremely pathogenic avian and swine influenza viruses paint a morbid picture of the emergence of a more lethal influenza virus in future. Currently, hypodermic needles are being dominantly employed in...
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Diabetes and Influenza-Attributable Illness: The Rationale for Targeted Influenza Vaccinations in Adults with Diabetes
DownloadFall 2012
While guidelines for seasonal influenza vaccinations single out working age (< 65) adults with diabetes, vaccination rates in this group remain below national targets. Historically, there has been limited evidence to support these guidelines. This dissertation comprises four studies investigating...
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Spring 2020
Introduction: Inflammatory bowel disease (IBD), which is consisted of ulcerative colitis (UC) and Crohn’s disease (CD), is a relapsing-remitting inflammatory condition of gastrointestinal tract. Although the exact pathophysiology of IBD is not known yet, it has been suggested that a combination...
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Environmental Exposures, Gut Microbiota, and Urinary Metabolomic Fingerprint of Crohn’s Disease Patients Who Have Undergone Ileo-colonic Resection
DownloadSpring 2014
Inflammatory bowel disease (IBD) is an idiopathic disease that causes intestinal inflammation and lesions. Canada has one of the highest rates of IBD in the world. One of the major types of IBD is Crohn’s Disease (CD) and a large portion of CD patients will undergo surgical resection in the...
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Fall 2009
Inflammatory Bowel Diseases (IBD) result from the nexus of a genetic predisposition, dysregulated immunologic insult against commensal microflora, and an environmental trigger. The intestinal epithelium is a single cell layer that separates a highly active mucosal immune system from a large...
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Spring 2018
Background- Crohn's disease (CD) is a type of inflammatory bowel disease that can cause inflammation throughout the alimentary tract. Many individuals diagnosed with CD ultimately require intestinal resection. Unfortunately, disease often recurs following surgery. The pathophysiology of the...
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Implementing and Evaluating Virtual Mindfulness-Based Stress Reduction for Adults with Inflammatory Bowel Disease
DownloadFall 2023
Inflammatory bowel diseases (IBD), which include Crohn’s disease and ulcerative colitis, are chronic diseases of the gastrointestinal tract. Individuals living with IBD suffer from chronic symptoms of fatigue and malnutrition and unpredictable flares of acute symptoms including abdominal pain,...