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Skip to Search Results- 1Afsaneh Lavasanifar (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Baker, Kristi (Oncology, Medical Microbiology and Immunology)
- 1Dr. Afsaneh Lavasanifar (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Mazurak, Vera (Agricultural, Food and Nutritional Science)
- 1Michael Weinfeld (Department of Oncology, Faculty of Medicine and Dentistry)
- 1Yasui, Yutaka (Public Health Sciences)
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Candidate-Pathway Gene Environment Interactions on Colon and Rectal Cancer Risk and Survival: Methodological Frameworks for Interaction in Genetic Association Studies
DownloadFall 2014
Genetic association studies have adopted for a long time a traditional analytic approach that focuses on individual genetic markers, usually single nucleotide polymorphisms (SNPs), in association with disease or phenotype. A standard single-SNP analysis that ignores combined effects of multiple...
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Elevated Fatty Acid Content in Muscle is Prevented by EPA and DHA in an Animal Model of Colorectal Cancer Receiving CPT-11 / 5-FU
DownloadFall 2012
This study aimed to assess the effect of irinotecan / 5-fluorouracil treatment on amount and types of fatty acids in skeletal muscles of tumor-bearing rats fed: a) control diet, b) fish oil diet. Rats bearing the Ward colorectal carcinoma were fed a semi-purified diet with or without fish oil...
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Spring 2022
Targeting DNA repair enzymes has attracted much attention in recent years to overcome the therapeutic resistance in cancer therapy. Inhibition of DNA repair enzymes can be used to make cancer cells sensitive to the DNA damaging effect of ionizing radiation or chemotherapy. In addition, the...
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Nanodelivery of Novel Inhibitors of ERCC1/XPF for sensitizing colorectal cancer cell to platinum drugs
DownloadSpring 2023
This project's long-term goal is to increase the efficacy of genotoxic therapeutics through thesensitization of cells to DNA-damaging therapy ahead of the treatment. The focus of this projectwas on the enhancement of platinum-based chemotherapeutics in colorectal cancer usingcolorectal cancer...
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The contribution of Sting and Nlrp3 activation to anti-tumour immunity in microsatellite instable colorectal cancer
DownloadFall 2019
The constant exposure of the intestine to antigens forces the mucosal immune system to be tolerant to avoid a constitutively inflamed state. Unfortunately, immune tolerance can allow colorectal cancers (CRCs) to escape detection. The majority of CRCs are chromosomally instable (CIN) and display...