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Skip to Search Results- 1Almasud, Alaa A
- 1Davis-Street, Janis.
- 1Fillmore, Natasha
- 1Friesen, Douglas E
- 1Gingras, Jacqueline Rochelle.
- 1Lemos Pinto Oliveira, Camila
- 5Department of Agricultural, Food, and Nutritional Science
- 2Department of Oncology
- 2Department of Pharmacology
- 2Faculty of Pharmacy and Pharmaceutical Sciences
- 1Department of Foods and Nutrition
- 1Department of Home Economics
- 1Afsaneh Lavasanifar (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Baker, Kristi (Oncology, Medical Microbiology and Immunology)
- 1Carla M. Prado (Agricultural, Food, and Nutritional Science)
- 1Dr. Afsaneh Lavasanifar (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Lopaschuk, Gary (Department of Pediatrics and Department of Pharmacology)
- 1Lopaschuk, Gary (Medical Sciences - Paediatrics)
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Spring 2016
Heart failure is associated with major changes in cardiac energy metabolism that decrease cardiac efficiency, which can reduce cardiac function. In severe heart failure there is a shift back toward a fetal heart metabolism, with a decrease in mitochondrial oxidative metabolism and increase in...
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Microtubules and Energy Metabolism: Targets for Standard, Combination, and Novel Therapeutic Interventions and Monitoring of Cancer
DownloadSpring 2016
The challenge of understanding and treating cancer has proven to be exceedingly complex. At this juncture, understanding cancer from the perspective of a breakdown of a complex cooperative system using a biophysical analysis may aid in improved treatments and prevention of this disease. In any...
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Spring 2022
Targeting DNA repair enzymes has attracted much attention in recent years to overcome the therapeutic resistance in cancer therapy. Inhibition of DNA repair enzymes can be used to make cancer cells sensitive to the DNA damaging effect of ionizing radiation or chemotherapy. In addition, the...
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Nanodelivery of Novel Inhibitors of ERCC1/XPF for sensitizing colorectal cancer cell to platinum drugs
DownloadSpring 2023
This project's long-term goal is to increase the efficacy of genotoxic therapeutics through thesensitization of cells to DNA-damaging therapy ahead of the treatment. The focus of this projectwas on the enhancement of platinum-based chemotherapeutics in colorectal cancer usingcolorectal cancer...
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The contribution of Sting and Nlrp3 activation to anti-tumour immunity in microsatellite instable colorectal cancer
DownloadFall 2019
The constant exposure of the intestine to antigens forces the mucosal immune system to be tolerant to avoid a constitutively inflamed state. Unfortunately, immune tolerance can allow colorectal cancers (CRCs) to escape detection. The majority of CRCs are chromosomally instable (CIN) and display...