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Skip to Search Results- 4Polymorphisms
- 1 Genome wide association study
- 1 SNP(s)
- 1 Single Nucleotide Polymorphism
- 1Adaptive immunity
- 1Antigen presentation
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Fall 2012
The recognition of virus infected cells by cytotoxic T lymphocytes is dependent on antigen presentation by MHC class I on the cell surface. Antigen presentation is critically dependent on the transporter associated with antigen processing (TAP), which facilitates the transport of peptides across...
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Cervid Prion Protein Polymorphisms Modulate the Diversity of Chronic Wasting Disease Prion Strains
DownloadSpring 2017
Chronic wasting disease (CWD) is a contagious prion disease spreading and emerging in wild and captive Cervidae species worldwide. Prion diseases are fatal neurodegenerative disorders occurring in various mammalian species including deer, elk, sheep, cattle and humans. Central to prion...
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Identification and Characterization of a Novel Premenopausal Breast Cancer Locus and Insights into Copy Number Variations for Disease Predisposition and Prognosis
DownloadFall 2018
Breast cancer is a complex multifactorial disease with the interplay of genetic, environmental and lifestyle factors contributing to the disease risk. Studies based on twins estimated that ~30% of the risk is due to genetic factors. High and moderate penetrant mutations along with low penetrance...
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Identity, conflict and radical coalition building: a study of grassroots organizing in Northern Ireland
DownloadSpring 2010
Coalitions in Northern Ireland have been organizing across the ethno-nationalist divide for decades. Yet, while empirical research has addressed challenges of, and potential for, organizing across ethnonationalism, the ways in which coalition members attend to their complex subjectivites have...
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Implications of genetic diversity on expression of LILRB1 in Natural Killer cells and susceptibility to HCMV infection in transplant patients
DownloadFall 2016
Leukocyte Ig-like Receptor 1 (LILRB1) is an inhibitory receptor expressed on a number of immune cells. The expression profile on NK cells is variable between people, with a range of 25-80% of NK cells expressing LILRB1. We previously uncovered a correlation between genotype within the 5’ end of...