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- 7Electrospray ionization mass spectrometry
- 6Library screening
- 4Lipids
- 3Mass-spectrometry
- 3Polysaccharides
- 12Chemistry, Department of
- 12Chemistry, Department of/Journal Articles (Chemistry)
- 11Graduate and Postdoctoral Studies (GPS), Faculty of
- 11Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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Structure and stability of carbohydrate-lipid interactions: Methylmannose polysaccharide-fatty acid complexes
Download2016
Mayer, Paul M., Richards, Michele R., Lowary, Todd L., Renaud, Justin, Klassen, John S., Tieleman, D. Peter, Kitova, Elena N., Liu, Lan, Siuda, Iwona
We report a detailed study of the structure and stability of carbohydrate–lipid interactions. Complexes of a methylmannose polysaccharide (MMP) derivative and fatty acids (FAs) served as model systems. The dependence of solution affinities and gas-phase dissociation activation energies (Ea) on FA...
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Studies Towards Understanding the Biosynthesis of Methyl Phosphoramidates found in Campylobacter jejuni
DownloadFall 2016
The human pathogen Campylobacter jejuni is the leading cause of food-borne gastroenteritis, causing more foodborne illnesses than Salmonella, Shigella, and Listeria combined. Of the approximate 5.3 million people infected every year in North America alone, approximately 1/1000 will develop the...
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Study of Non-Covalent Protein-Carbohydrate Interactions using Electrospray Ionization Mass Spectrometry
DownloadFall 2012
This thesis describes the development and application of electrospray ionization mass spectrometry (ESI-MS) methods to study protein-carbohydrate interactions in vitro. The affinities (Ka) of two recombinant fragments of Clostridium difficile toxins (TcdA & TcdB) and a library of the most...
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Fall 2013
Solubility of glucose and lactose in subcritical water (SCW) was first determined at different pressures and temperatures. Sugar solubility increased with temperature but decreased with an increase in pressure. Then, carbohydrates and phenolics were extracted from lentil husk and cotyledon using...
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The Design, Synthesis and Evaluation of Multivalent Heterobifunctional Ligands Specific for Shiga Toxin 1 and Shiga Toxin 2
DownloadSpring 2014
Hemolytic uremic syndrome (HUS) is a potential life-threatening condition caused by infection with Shiga toxin-producing Escherichia coli O157:H7. There are two major types of Shiga toxins, namely, Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2), of which, Stx2 is clinically most closely associated...